The paradoxical hedonic valence of acute ethanol withdrawal (hangover) states in rats: place and taste conditioning

Alcohol
D V GauvinF A Holloway

Abstract

The hedonic valence of EtOH's delayed effects, usually referred to as "hangover," was assessed 18 h after a 4 g/kg injection using both place and taste learning tasks. In the place conditioning task two CS-,CS+ intervals were used (48 h and 144 h); within each treatment interval, experimentally induced "hangover" was paired with the initially nonpreferred conditioning compartment for half of the experimental group (N = 10 rats) and with the initially preferred conditioning compartment for the half (N = 10 rats). Saline injections were paired with placement in the alternate conditioning compartment. A third group (N = 10 rats) was conditioned with milliliter equivalent volumes of saline on both sides. A conditioned place preference was conditioned with the hangover state-induced interoceptive stimuli. Attempts were made to taste condition 24 rats with the interoceptive stimulus attributes of hangover. Experimentally induced hangover was associated with an adipsogenic state, defined as a significant decline in voluntary intake of both saccharin and water, which prevented taste conditioning.

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Citations

Oct 3, 2006·Psychopharmacology·Peter G RomaAnthony L Riley
Apr 6, 2013·Behavioural Brain Research·Analía G Karadayian, Rodolfo A Cutrera
Jul 23, 2003·Pharmacology, Biochemistry, and Behavior·Tamara L DoremusLinda Patia Spear
May 1, 1997·Pharmacology, Biochemistry, and Behavior·D V GauvinF A Holloway
Jan 13, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Rui D S PredigerReinaldo N Takahashi
Jul 5, 2008·Physiology & Behavior·Rachel N DingleVincent M Lolordo
Mar 17, 2005·Alcoholism, Clinical and Experimental Research·Hilary J LittleChristopher Cunningham
Sep 1, 2007·Alcoholism, Clinical and Experimental Research·Tamara L Doremus-Fitzwater, Linda P Spear
May 29, 1999·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·S L Blatt, R N Takahashi

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