The paradoxical role of thioredoxin on oxidative stress and aging

Archives of Biochemistry and Biophysics
Geneva M CunninghamYuji Ikeno

Abstract

In spite of intensive study, there is still controversy about the free radical or oxidative stress theory of aging, particularly in mammals. Our laboratory has conducted the first detailed studies on the role of thioredoxin (Trx) in the cytosol (Trx1) and in mitochondria (Trx2) on oxidative stress and aging using unique mouse models either overexpressing or down-regulating Trx1 or Trx2. The results generated from our lab and others indicate that: (1) oxidative stress and subsequent changes in signaling pathways could have different pathophysiological impacts at different stages of life; (2) changes in redox-sensitive signaling controlled by levels of oxidative stress and redox state could play more important roles in pathophysiology than accumulation of oxidative damage; (3) changes in oxidative stress and redox state in different cellular compartments (cytosol, mitochondria, or nucleus) could play different roles in pathophysiology during aging, and their combined effects show more impact on aging than changes in either oxidative stress or redox state alone; and (4) the roles of oxidative stress and redox state could have different pathophysiological consequences in different organs/tissues/cells or pathophysiological conditio...Continue Reading

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Citations

Mar 24, 2016·Journal of the Neurological Sciences·Jun-Xia DaiHua-Jun Ba
Jan 18, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·Song-Quan QianGuang-Hua Pan
Feb 18, 2016·Oxidative Medicine and Cellular Longevity·Aysegul CortLiudmila Korkina
Mar 31, 2016·Cancers·Yuxin ChenWang Min
Jun 2, 2016·Oxidative Medicine and Cellular Longevity·Pierpaola DavalliDomenico D'Arca
Jun 15, 2016·Annual Review of Biochemistry·Celine E RieraAndrew Dillin
Aug 30, 2016·Ageing Research Reviews·Holly M Brown-Borg, Rochelle Buffenstein
Jan 24, 2017·Clinica Chimica Acta; International Journal of Clinical Chemistry·Zhe-Ming XuChang Tao
Apr 26, 2017·Annual Review of Biochemistry·Helmut SiesDean P Jones
Sep 15, 2017·Lipids in Health and Disease·Saijun ZhouPei Yu
Aug 28, 2020·Biological Chemistry·Xiankun CaoAn Qin
Mar 29, 2020·Frontiers in Oncology·Zhimin MaoJian Yao
Jul 24, 2020·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Harvey I PassChandra M Goparaju
Jan 3, 2020·Nutrition Research·Sara Salucci, Elisabetta Falcieri
Dec 20, 2020·International Journal of Environmental Research and Public Health·Mariarita BrancaccioOlga Scudiero
Jan 20, 2019·Mechanisms of Ageing and Development·Emmanuel MoyseCharles Ramassamy
Oct 6, 2020·Thoracic Surgery Clinics·Harvey I PassChandra M Goparaju
Aug 28, 2021·Antioxidants·Munsoo HanTae Hoon Kim
Sep 16, 2021·Journal of Biochemistry·Nusrat PerweenSaroj S Ghaskadbi

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