The parasitic ciliate Ichthyophthirius multifiliis induces expression of immune relevant genes in rainbow trout, Oncorhynchus mykiss (Walbaum)

Journal of Fish Diseases
J SighK Buchmann

Abstract

Abstract During an infection with the parasitic ciliate Ichthyophthirius multifiliis, expression of genes encoding complement factor C3, inducible nitric oxide synthase (iNOS), immunoglobulin (IgM) and major histocompatibility complex (MHC-II) was examined in the skin, head kidney and spleen of rainbow trout using semi-quantitative reverse transcriptase-polymerase chain reaction. Induction of C3 transcription levels was evident in the skin and spleen showing extra-hepatic production of C3. MHC-II and IgM levels were increased in both head kidney and skin suggesting a production of antibodies at the site of infection, as well as in the lymphoid organs. iNOS expression was only increased briefly in the skin during the infection. These data suggest that complement is involved in immune reactions against I. multifiliis and that mucosal antibodies might be produced at the site of infection.

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Citations

Jul 3, 2013·Developmental and Comparative Immunology·H W Dickerson, R C Findly
Jan 20, 2006·The Journal of Parasitology·Benjamin J DoddRonald V Dimock
Jan 9, 2013·Fish & Shellfish Immunology·Norashikin Mohd-ShaharuddinSheila Nathan
Jan 17, 2012·Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics·Laura M BradenSimon R M Jones
Dec 14, 2011·Fish & Shellfish Immunology·Aijun LüGuangzhou Zhou
Jan 26, 2011·Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics·Christopher Marlowe A CaipangViswanath Kiron
Sep 12, 2008·Veterinary Immunology and Immunopathology·Pilar Alvarez-Pellitero
Nov 30, 2007·Developmental and Comparative Immunology·Xiguang ZhaoHarry W Dickerson
Oct 20, 2006·Molecular Immunology·Santiago Fernandez GonzalezAndrew Cossins
Jun 14, 2005·Fish & Shellfish Immunology·H BoshraJ O Sunyer
Apr 6, 2016·Fish & Shellfish Immunology·De-Hai XuGabriel S A Moreira
Sep 18, 2015·Frontiers in Immunology·Hetron Mweemba Munang'anduØystein Evensen

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