The Paris System for Reporting Urinary Cytology reduces atypia rates and does not alter the negative predictive value of urine cytology.

Journal of the American Society of Cytopathology : JASC
Patrick J McIntireGüliz A Barkan

Abstract

The Paris System for Reporting Urinary Cytology (TPS) was developed for standardization purposes and it placed an emphasis on screening for high-grade urothelial carcinoma (HGUC). Since then, it has shown to reduce atypia rates and better correlate with surgical specimens. The aim of this study was to calculate the negative predictive value (NPV) of urinary cytology for detecting HGUC using TPS and compare these data to our recently published pre-TPS cohort. As a screening test, it is imperative that TPS has a high NPV. A search of our institution's pathology database for the term "negative for HGUC" from January 1, 2016, to December 31, 2017, was conducted. A true negative was defined as a patient with at least 1 subsequent negative urine cytology/surgical biopsy specimen or the patient being clinically negative for 6 months. NPV rates were calculated based on the data obtained. The cohort consisted of 2960 urine cytology specimens from 1894 patients. A total of 99 false negatives were identified, generating a NPV of 96.7% (2861/2960). This NPV is identical to our previously published pre-TPS cohort (years 2012-2013; NPV: 96.7%). The clinical indication most effected NPV, with a history of urothelial carcinoma with a NPV of 93...Continue Reading

References

May 5, 1999·International Journal of Urology : Official Journal of the Japanese Urological Association·N MiyanagaK Koiso
Mar 4, 2000·The Urologic Clinics of North America·F M Brown
Aug 18, 2004·The Journal of Urology·Grethchen L SchroederVinata Lokeshwar
Sep 25, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Bernard TêtuYves Fradet
Mar 23, 2005·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·B PlanzA Boecking
May 20, 2005·American Journal of Obstetrics and Gynecology·Eric R SokolDeborah L Myers
Feb 1, 1947·The Journal of Urology·G N PAPANICOLAOU
Oct 20, 2012·The Journal of Urology·Said F MishrikiBhaskar Somani
Mar 29, 2013·Cancer Cytopathology·Julianne Muus UbagoGüliz A Barkan
May 26, 2016·Cytopathology : Official Journal of the British Society for Clinical Cytology·C J VandenBussche
May 28, 2016·Advances in Anatomic Pathology·Güliz A BarkanDorothy L Rosenthal
Apr 6, 2017·Acta Cytologica·Kiran MalviyaMona Agnihotri
Dec 19, 2017·Cytopathology : Official Journal of the British Society for Clinical Cytology·X ZhengD C Chhieng

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