The pars tuberalis of the ewe: no effect of season or ovariectomy on the distribution, density or presence of immunoreactive cells

Cell and Tissue Research
D C Skinner, J E Robinson

Abstract

This study investigated whether season or long-term ovariectomy influence the presence, distribution and density of immunoreactive cells in the ovine pars tuberalis. Three groups of ewes were used: breeding season (BS; n=5), anoestrous (AS; n=8) and ovariectomised (OVX; n=4). Two rams were also investigated for possible sex-dependent differences. Employing standard immunocytochemical techniques, paraformaldehyde-fixed sagittal pars tuberalis and pars distalis sections were immunoreacted against luteinising hormone, luteinising hormone beta-subunit, thyroid-stimulating hormone, prolactin, growth hormone, beta-endorphin and adrenocorticotrophic hormone. Numerous gonadotrophs were detected in the anteroventral region of the pars tuberalis and there was no significant difference in the density (gonadotrophs/0.01 mm2; BS: 44+/-13, AS: 29+/-2, OVX: 27+/-4) or percentage of total cells (%; BS: 48+/-8, AS: 45+/-4, OVX: 49+/-2); the rams also appeared similar (27+/-2 gonadotrophs/0.01 mm2; 49+/-1%). In contrast, few gonadotrophs (less than 1%) were detected in the anterodorsal and posterior pars tuberalis regions. Apart from occasional thyrotrophs in the anteroventral pars tuberalis (less than 4%), no other pars distalis hormone-contain...Continue Reading

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