The Past Informs the Future: An Overview of the Million Worker Study and the Mallinckrodt Chemical Works Cohort

Health Physics
John D BoiceRichard W Leggett

Abstract

The purpose of this paper is to present an overview of ongoing work on the Million Worker Study (MWS), highlighting some of the key methods and progress so far as exemplified by the study of workers at the Mallinckrodt Chemical Works (MCW). The MWS began nearly 25 y ago and continues in a stepwise fashion, evaluating one study cohort at a time. It includes workers from U.S. Department of Energy (DOE) Manhattan Project facilities, U.S. Nuclear Regulatory Commission (NRC) regulated nuclear power plants, industrial radiographers, U.S. Department of Defense (DoD) nuclear weapons test participants, and physicians and technologists working with medical radiation. The purpose is to fill the major gap in radiation protection and science: What is the risk when exposure is received gradually over time rather than briefly as for the atomic bomb survivors? Studies published or planned in 2018 include leukemia (and dosimetry) among atomic veterans, leukemia among nuclear power plant workers, mortality among workers at the MCW, and a comprehensive National Council on Radiation Protection and Measurements (NCRP) Report on dosimetry for the MWS. MCW has a singular place in history: the 40 tons (T) of uranium oxide produced at MCW were used by ...Continue Reading

References

Jul 20, 2000·American Journal of Epidemiology·E Dupree-EllisJ Phillips
Jun 21, 2001·Epidemiology·K SteenlandG M Calvert
Apr 20, 1963·Nature·J B HURSH, A LOVAAS
Jul 6, 2004·American Journal of Epidemiology·Shannon C BrownA James Ruttenber
Jul 22, 2008·Health Physics·Ronald L Kathren, Richard K Burklin
Jan 1, 2015·Health Physics·André BouvilleCary Zeitlin
Jan 13, 2015·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·Maia AvtandilashviliSergei Y Tolmachev
Jun 30, 2016·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·Glyn G CaldwellJohn D Boice
Jul 28, 2016·Lancet·Amit C NathwaniJohn D Harrison
Jan 31, 2017·Radiation Research·Harold L BeckPaul G Voillequé
Feb 6, 2017·International Journal of Radiation Biology·R Julian Preston
Feb 25, 2017·Health Physics·John D Boice
Mar 28, 2017·International Journal of Radiation Biology·Werner RühmJan Christian Kaiser
Apr 20, 2017·International Journal of Radiation Biology·Roy ShoreWerner Rühm
May 24, 2017·International Journal of Radiation Biology·John D Boice

❮ Previous
Next ❯

Citations

Jul 26, 2018·Health Physics·John D BoiceElizabeth D Ellis
Jul 14, 2018·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·R E ShoreL T Dauer
Nov 10, 2018·International Journal of Radiation Biology·Michael T MummaJohn D Boice
Nov 20, 2018·International Journal of Radiation Biology·Sarah S CohenJohn D Boice
Dec 2, 2018·International Journal of Radiation Biology·Ashley P GoldenJohn D Boice
Nov 20, 2018·International Journal of Radiation Biology·Robert C YoderRichard J Vetter
Dec 5, 2018·International Journal of Radiation Biology·Richard W LeggettJohn D Boice
Dec 19, 2018·International Journal of Radiation Biology·Richard W LeggettMichael Bellamy
Jan 8, 2019·International Journal of Radiation Biology·John D BoiceSarah S Cohen
Mar 5, 2019·International Journal of Radiation Biology·John D Boice
Mar 5, 2019·International Journal of Radiation Biology·John D BoiceElizabeth D Ellis
Jul 5, 2019·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·John D BoiceRoy Shore
Apr 16, 2020·Journal of Neurophysiology·Gilles R ClémentWilliam H Paloski
Jan 18, 2019·International Journal of Radiation Biology·Ashley P GoldenJohn D Boice
Oct 26, 2018·International Journal of Radiation Biology·Derek HagemeyerTerry A Brock
Aug 16, 2018·British Journal of Cancer·Richard Wakeford
Apr 3, 2020·International Journal of Environmental Research and Public Health·Soojin ParkYoung Woo Jin
Jul 9, 2020·Environmental Science and Pollution Research International·Yuliya SemenovaGeir Bjørklund
May 11, 2021·International Journal of Radiation Biology·Ashley P GoldenLydia B Zablotska
Jun 24, 2021·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·Richard Wakeford
Dec 18, 2021·International Journal of Radiation Biology·Vinita ChauhanKnut Erik Tollefsen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.