The past, present and future of antifolates in the treatment of Plasmodium falciparum infection

The Journal of Antimicrobial Chemotherapy
A M Nzila

Abstract

Chemotherapy remains the most important means of controlling malaria, one of the deadliest infectious parasitic diseases in the world. Antimalarial antifolates have been central for prophylaxis and treatment of malaria. This drug family was discovered in the 1940s, during the Second World War, and molecules that are currently in clinical use were discovered at that time. Since the 1940s, no new antimalarial antifolates have been developed that have reached Phase I/II stages. Limited work has been carried out to exploit the inhibition of the malaria folate pathway as a means of discovering new drugs. In this review, work carried out on antimalarial antifolates since the 1940s up to the present time is discussed in terms of discovery, clinical use, mode of action and mechanism of resistance. New concepts have been presented to improve antimalarial antifolate in vivo efficacy and to identify potent new antifolate agents.

Citations

Aug 19, 2011·Parasitology Research·Sanjeev ChandelNisha Vashishat
Jan 22, 2009·Journal of Computer-aided Molecular Design·Phornphimon MaitaradSupa Hannongbua
Mar 8, 2014·European Journal of Medicinal Chemistry·Theunis T CloeteDavid D N'Da
Jan 11, 2013·Journal of Medicinal Chemistry·Caitriona McKeeverIsabel Rozas
Dec 22, 2009·The Journal of Antimicrobial Chemotherapy·Alexis Nzila, Leah Mwai
Sep 2, 2011·Future Medicinal Chemistry·Alexis NzilaKelly Chibale
Dec 14, 2012·Future Medicinal Chemistry·Nyaradzo T L Chigorimbo-MurefuKelly Chibale
Jul 18, 2012·Future Medicinal Chemistry·Moni Sharma, Prem M S Chauhan
Aug 19, 2014·Trends in Parasitology·Didier LeroyStéphanie Cherbuin
Feb 1, 2008·Expert Opinion on Therapeutic Patents·David B BolstadAmy C Anderson
Mar 19, 2013·Molecular and Biochemical Parasitology·Ingrid B Müller, John E Hyde
Nov 22, 2012·Bioorganic & Medicinal Chemistry·Stefan I PretoriusDavid D N'Da
Sep 30, 2008·Bioorganic & Medicinal Chemistry·Jean GuillonPhilippe Grellier
May 3, 2008·Trends in Parasitology·Erica L Dahl, Philip J Rosenthal
Mar 21, 2007·Trends in Parasitology·Vivian N HawkinsCarol Hopkins Sibley
Feb 26, 2008·Archiv der Pharmazie·Martin Schlitzer
Feb 27, 2008·Chemical Biology & Drug Design·Nitendra K SahuDharm Veer Kohli
Sep 11, 2007·The FEBS Journal·John E Hyde
Sep 10, 2014·Journal of Computational Chemistry·Minhajul ArfeenPrasad V Bharatam
Mar 15, 2011·Drug Development Research·Francis W Muregi, Akira Ishih
Jun 14, 2014·Andrology·O Gutiérrez-PérezR M Vigueras-Villaseñor
Sep 26, 2006·Drug Discovery Today·Alexis Nzila
Sep 24, 2015·Acta Crystallographica. Section E, Crystallographic Communications·Pattarapol KhongsukPalangpon Kongsaeree
Jan 13, 2015·Bioorganic & Medicinal Chemistry·Kathryn J WichtTimothy J Egan
Oct 22, 2014·Journal of Biomolecular Structure & Dynamics·Sheenu AbbatPrasad V Bharatam
Apr 23, 2015·European Journal of Medicinal Chemistry·César Mendoza-MartínezFrancisco Hernández-Luis
May 28, 2014·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Sekineh PirahmadiSedigheh Zakeri
Nov 27, 2009·Trends in Parasitology·Ingrid B MüllerCarsten Wrenger
Feb 14, 2014·BioMed Research International·Thales KronenbergerCarsten Wrenger
Oct 25, 2011·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Mandana AfsharpadNavid D Djadid
Jan 9, 2010·Trends in Parasitology·Alexis NzilaTim Niehues
Apr 29, 2014·Journal of Ethnopharmacology·Camille DesgrouasEvelyne Ollivier

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