PMID: 9529611Apr 8, 1998Paper

The patched gene in development and cancer

Current Opinion in Genetics & Development
P W Ingham

Abstract

The cloning of vertebrate homologues of the Drosophila segment polarity gene patched has led to confirmation of a role for the multipass transmembrane protein which it encodes as a receptor for secreted signalling proteins of the Hedgehog family. In addition, human patched has been identified as a tumour suppressor gene implicated in basal cell carcinomas and medullablastomas.

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