The patched polymorphism Pro1315Leu (C3944T) may modulate the association between use of oral contraceptives and breast cancer risk

International Journal of Cancer. Journal International Du Cancer
Jenny Chang-ClaudeHeidi Hahn

Abstract

The gene coding for the human homologue of the Drosophila segment polarity gene patched (PTCH1) is mutated in several common human tumors. In mice, haplodeficiency at the Ptch1 locus results in severe histologic defects in mammary ductal structure. We found no mutations within the coding region of PTCH1 in 17 human primary breast carcinomas. However, the biallelic Pro1315Leu (C3944T) polymorphism of PTCH1 was significantly associated with breast cancer in 41 Bavarian patients compared to 85 healthy controls. We investigated whether this variant influences susceptibility for breast cancer in 611 breast cancer patients diagnosed by age 50 years and 1,057 controls matched by age and study region in Germany and in 1,093 breast cancer patients from the United Kingdom. Allele and genotype frequencies were not different between cases and controls. However, multivariate logistic regression analysis revealed an effect modification of oral contraceptive use (OC) on breast cancer risk by Leu-carrier status. Compared to women who have Pro/Pro and never used OC, Pro/Pro OC users had an increased odds ratio for breast cancer of 1.7. The odds ratio was also 1.7 for Leu-carriers who never used OC, but this was attenuated among Leu-carriers who...Continue Reading

References

Jan 1, 1993·Epidemiologic Reviews·L Bernstein, R K Ross
Jun 5, 1998·The Journal of Biological Chemistry·R B PepinskyA Galdes
Sep 4, 1999·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·H HahnA Zimmer
Oct 3, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·I VorechovskýRune Toftgård
Nov 7, 2000·Cancer Causes & Control : CCC·Jenny Chang-ClaudeH Becher
Dec 29, 2000·Cellular and Molecular Life Sciences : CMLS·Rune Toftgård
Oct 16, 2001·Nature Genetics·J P IoannidisD G Contopoulos-Ioannidis
Apr 5, 2002·Trends in Genetics : TIG·Patricia E Kuwabara, Michel Labouesse
Aug 31, 2002·Human Mutation·Julia Calzada-WackHeidi Hahn

Citations

Jun 20, 2008·Breast Cancer Research and Treatment·Xiaomei ZhangMichael T Lewis
May 30, 2009·Breast Cancer Research and Treatment·M F BarginearD R Budman
Jul 12, 2007·Journal of Mammary Gland Biology and Neoplasia·Sarah Hatsell, Andra R Frost
Feb 25, 2009·Carcinogenesis·Maria KasperRune Toftgård
Aug 18, 2006·Molecular and Cellular Biology·Erica NieuwenhuisChi-Chung Hui
Jul 1, 2005·Breast Cancer Research : BCR·Suling LiuMax S Wicha
Jan 13, 2006·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·M A MansillaJ C Murray
Apr 11, 2008·Stem Cell Reviews·César CobaledaJesús Pérez-Losada
Jun 29, 2007·Human Pathology·Christian HafnerThomas Vogt
Dec 16, 2004·Annals of Human Genetics·Richard C StrangePaul R Hoban
May 13, 2005·The British Journal of Dermatology·A AsplundF Pontén
Nov 19, 2005·The Journal of Pathology·Helen Kalirai, Robert B Clarke
Jun 14, 2013·Birth Defects Research. Part A, Clinical and Molecular Teratology·Zhen WangYi Luo
Mar 30, 2010·The British Journal of Dermatology·A BegniniM Gomez Lira
Oct 15, 2013·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Hope M AmmMary MacDougall
Aug 20, 2005·Journal of Dental Research·T KawabataT Iizuka
Apr 28, 2019·Cells·Natalia A Riobo-Del GaldoEva V Wertheimer
Apr 23, 2020·International Journal of Oncology·Lu XiaLu-Zhe Sun
Nov 11, 2019·Scientific Reports·Chih-Yang WangHui-Ping Hsu
Jan 15, 2011·Virchows Archiv : an International Journal of Pathology·Karoliina StefaniusAuli Karhu
Nov 13, 2020·The Journal of Dermatology·Thilo GambichlerJürgen C Becker
Sep 17, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shintaro NaritaMartin E Gleave

Related Concepts

Mammary Neoplasms, Human
Oral Contraceptives, Phasic
Disease Susceptibility
Cell Surface Proteins
Genetic Polymorphism
Hormone Receptors, Cell Surface
Odds Ratio
Nested Case-Control Studies
Nested Polymerase Chain Reaction
Premenopause

Related Feeds

Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.

Carcinoma, Lobular

Lobular carcinoma is an invasive type of breast cancer in which lobules, areas of the breast that produce milk, undergo malignant transformation. Here is the latest research.