The paternal effect gene ms(3)sneaky is required for sperm activation and the initiation of embryogenesis in Drosophila melanogaster

Developmental Biology
Karen R Fitch, B T Wakimoto

Abstract

Although a large number of maternal factors are known to be essential for fertilization or the earliest stages of embryogenesis in Drosophila melanogaster, the role of paternally supplied products is not clearly understood. Paternal effect mutations provide a means to identify factors specifically required by the sperm after its entry into the egg. Here we describe the third strict paternal effect gene to be identified in Drosophila ms(3)sneaky(snky), which defines the earliest developmental arrest phenotype so far described. Characterization of two independently isolated snky mutations showed that they affected male fertility, but not viability or female fertility. Cytological analyses showed that spermatogenesis proceeded normally in snky males. However, the snky defect was evident after sperm entry into the egg; snky sperm did not undergo nuclear decondensation, form a functional male pronucleus, or initiate mitotic divisions in the egg. Immunolocalization of tubulin and Drosophila Centrosomin, a known centrosomal component, showed that snky-inseminated eggs failed to reconstitute a microtubule-organizing center. In addition, snky sperm chromatin retained the histochemical properties of mature sperm chromatin for several hou...Continue Reading

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Citations

Feb 21, 2002·Molecular Biology of the Cell·Jing Yu, Mariana F Wolfner
Sep 24, 2004·Biology of Reproduction·Gaurishankar ManandharPeter Sutovsky
Mar 2, 2012·Proceedings. Biological Sciences·Bettina E FischerSteven Russell
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Aug 5, 2003·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Harriet L Harris, Henk R Braig
Jul 22, 2021·Annual Review of Cell and Developmental Biology·Victoria E Deneke, Andrea Pauli

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