The pathobiology of Alzheimer's disease

Annual Review of Medicine
G G Glenner

Abstract

The discovery of beta protein, the major component of the amyloid fibrils of the plaques and cerebral vessels and of the paired helical filaments of the neurofibrillary tangles, has provided a means to decipher the pathogenesis of Alzheimer's disease. The same lesions in aged Down's syndrome individuals have also been shown to be composed of beta protein. Gene probes localize the gene for beta protein, as well as that for familial Alzheimer's disease, to chromosome 21, but these genes are not linked. A study of posttranslational modifications of the 695-amino-acid beta-protein gene precursor, with specific reference to abnormal proteolysis, may provide insights into the cause of the amyloidotic lesions of Alzheimer's disease and the means of arresting them.

Citations

Aug 8, 2015·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Carla D'AvanzoDoo Yeon Kim
Sep 29, 2012·Journal of Neurochemistry·Lisa A RidnourCarol A Colton
Oct 6, 2006·Journal of Neuropathology and Experimental Neurology·María C LealLaura Morelli
Jun 13, 1991·Biochimica Et Biophysica Acta·R J MayerJ Lowe
Apr 15, 1994·Journal of Neuroscience Research·D K LahiriM R Farlow
May 7, 2019·Molecular Pharmaceutics·Virendra Kumar MeenaPuja Panwar Hazari

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