The pathobiology of polyomavirus infection in man

Advances in Experimental Medicine and Biology
Parmjeet RandhawaRon Shapiro

Abstract

This article traces the discovery of polyomaviruses and outlines investigations, which shed light on potential modes of transmission of this increasingly important group of human pathogens. The pathobiology of the virus is summarized with particular reference to interactions with host cell receptors, cell entry, cytoplasmic trafficking, and targeting of the viral genome to the nucleus. This is followed by a discussion of sites of viral latency and factors leading to viral reactivation. Finally, we present biochemical mechanisms that could potentially explain several key elements of tissue pathology characteristic of BKV mediated damage to human kidney.

Citations

Feb 9, 2007·Journal of Virology·Tobias AllanderBjörn Andersson
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Jun 29, 2012·Journal of Virology·Erica A SiebrasseDavid Wang
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Feb 26, 2016·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Anala GossaiMargaret R Karagas
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