PMID: 6538163Feb 1, 1984Paper

The pathogenesis and effect on renal function of nephrocalcinosis induced by different diets in female rats

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
M D StonardE A Lock

Abstract

The ability of three diets to produce nephrocalcinosis in female rats has been compared after 30, 60 and 90 days of feeding. Severe nephrocalcinosis with associated tubular damage was induced with a standard laboratory maintenance low-protein diet and with a diet containing a single-cell protein (Pruteen) but not with a casein-containing diet. Both the Pruteen and casein diets were high-protein diets. The development of the lesion was equally rapid following feeding of either the laboratory maintenance diet or the Pruteen diet. Nephrocalcinosis was present, with body kidneys similarly affected, at each 30-day interval with either diet. A severe degree of nephrocalcinosis was associated with widespread renal damage although signs of tubular regeneration and repair were evident at 30 days. Nephrocalcinosis induced by the Pruteen diet was accompanied by enlargement of the kidney. Renal function was assessed at each time by the measurement of urine volume, specific gravity and protein content, inulin clearance, and the excretion of the urinary enzymes N-acetyl-beta-glucosaminidase and alkaline phosphatase. Despite extensive calcification and some tubular damage, renal function was unimpaired, reflecting the capacity of the function...Continue Reading

References

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Citations

Apr 1, 1986·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J C PhillipsS D Gangolli
Sep 1, 1988·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J O'Brien, R Walker
Mar 1, 1989·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·G V MitchellE Grundel
May 1, 1990·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K W Miller, P H Long
Dec 1, 1993·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·D R WebbN E Fortier
Mar 1, 1994·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M E ShackelfordM W O'Donnell
Mar 1, 1992·The British Journal of Nutrition·J G SterckA C Beynen
Sep 22, 2005·Nutrition & Metabolism·William F MartinNancy R Rodriguez
Feb 27, 2008·Journal of Clinical Biochemistry and Nutrition·Hiroshi MatsuzakiMisao Miwa
Aug 3, 2011·Acta Cirúrgica Brasileira·Igor Eduardo Caetano FariasJoão Batista de Sousa
May 25, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Magali LacroixJean-François Huneau
Nov 24, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Allon N Friedman

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