The Pathogenesis and Immunobiology of Mousepox

Advances in Immunology
Luis J Sigal

Abstract

Ectromelia virus is a mouse-specific orthopoxvirus that, following footpad infection or natural transmission, causes mousepox in most strains of mice, while a few strains, such as C57BL/6, are resistant to the disease but not to the infection. Mousepox is an acute, systemic, highly lethal disease of remarkable semblance to smallpox, caused by the human-specific variola virus. Starting in 1929 with its discovery by Marchal, work with ECTV has provided essential information for our current understanding on how viruses spread lympho-hematogenously, the genetic control of antiviral resistance, the role of different components of the innate and adaptive immune system in the control of primary and secondary infections with acute viruses, and how the mechanisms of immune evasion deployed by the virus affect virulence in vivo. Here, I review the literature on the pathogenesis and immunobiology of ECTV infection in vivo.

Citations

Nov 8, 2017·Viruses·Graziele Pereira OliveiraJônatas Santos Abrahão
Feb 1, 2018·Vaccines·Sharon MelamedNir Paran
May 12, 2018·International Journal of Molecular Medicine·Wenyu ChengZhizhong Jing
Feb 1, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Katherine S ForsythLaurence C Eisenlohr
Mar 26, 2021·The Journal of Experimental Medicine·Maria FerezLuis J Sigal
Jul 3, 2021·Viruses·Carla MavianAntonio Alcamí
Nov 20, 2021·Immunological Reviews·Sophia M Vrba, Heather D Hickman

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