PMID: 9553564Apr 29, 1998Paper

The pathogenesis of bone loss following total knee arthroplasty

The Orthopedic Clinics of North America
P L LewisS E Graves

Abstract

Bone loss following total knee arthroplasty (TKA) may be focal or diffuse. It may be caused mechanically, either by unloading of the bone leading to disuse osteoporosis, or by overloading of the bone leading to trabecular fractures and bone destruction. Osteolysis, instigated by an inflammatory reaction to particulate wear debris, is an important and common cause of bone loss after TKA. Less common, though sometimes dramatic, causes of bone loss are infection and osteonecrosis.

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Jan 13, 2004·The Journal of Arthroplasty·Matthew C NadaudKeith Fehring
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