PMID: 8599437Jun 1, 1995Paper

The pathogenesis of familial multiple cylindromas, trichoepitheliomas, milia, and spiradenomas

The American Journal of Dermatopathology
S C van der Putte

Abstract

Early stages in the development of hereditary cylindromas associated with trichoepitheliomas, milia, and spiradenomas revealed that (a) trichoepitheliomas were derived from the bulges of hair follicles and probably represented an abnormal histogenesis from which rarely poorly differentiated trichoepitheliomas developed; (b) milia were the result of cystic alteration of the trichoepitheliomatous bulge proliferations; and (c) cylindromas and spiradenomas were different appearances of the same tumor and developed from two separate sources, follicular bulge proliferations and eccrine glands. From the bulge proliferations multiple cylindromatous buds developed that, by increasing in number, formed the classical cylindroma and, by increasing in size rather than in number, gave the spiradenomatous variant. Eccrine glands transformed into cylindromas by cylindromatous growth from the basal cell layer. Connections between the original structures and the tumors were mostly lost. Tumors from both sources revealed the same morphology, which was most indicative of eccrine differentiation including secretory and excretory elements. Apocrine differentiation was a rare and possibly secondary event. The multiplicity in derivation and differenti...Continue Reading

Citations

Dec 4, 2001·Journal of the European Academy of Dermatology and Venereology : JEADV·J C SzepietowskiR A Schwartz
Mar 27, 2003·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Maryanna C Ter PoortenJoel Cook
Oct 1, 1996·The American Journal of Dermatopathology·M T Fernández-FiguerasC Ferrándiz
Mar 21, 1998·The American Journal of Dermatopathology·L PuigJ M de Moragas
Jul 15, 2004·The American Journal of Surgical Pathology·Daisuke NonakaMichele Bisceglia
May 19, 2005·American Journal of Clinical Pathology·Jorge Albores-SaavedraAgnieszka K Witkiewicz
Sep 30, 2008·Journal of the American Academy of Dermatology·David R Berk, Susan J Bayliss
Jan 24, 2004·The Journal of Dermatology·Koji UedeFukumi Furukawa
Apr 30, 2004·Clinical and Experimental Dermatology·D KakagiaG Alexiadis
May 20, 2003·The Australasian Journal of Dermatology·Helen SaundersFrances Watkins
Apr 25, 2000·The Journal of Dermatology·S A CenturiónW C Lambert
Oct 1, 2016·Indian Journal of Dermatology·Cintia Arjona AguileraMario Linares Barrios
Feb 1, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·A Neil CrowsonMartin C Mihm
Jun 7, 2007·International Journal of Dermatology·Roberto Adrián RetamarE N Chouela

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Related Papers

The Medical Clinics of North America
R J Pariser
International Journal of Dermatology
L WaxteinL Dominguez-Soto
Journal of the American Academy of Dermatology
T S SebastienT M Johnson
Journal of Cutaneous Pathology
Teresa Tram N PhamChristopher Herman
© 2021 Meta ULC. All rights reserved