The pathogenesis of Graves' disease.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
R Volpé

Abstract

We have hypothesized over many years that Graves' disease (GD) and the other autoimmune thyroid diseases (AITD) are each due to antigen-specific defects in suppressor (regulatory) T lymphocyte function. There have been several reports dealing with the role of regulatory T lymphocyte subsets, ie., that will prevent autoimmune disease in these and other organ-specific autoimmune diseases. In AITD, suppressor T cells have been shown to be less well activated by relevant antigen, but are normally activated by irrelevant antigen; suppressor T cells from normal persons react equally well to both. In GD, these cells have been shown to be inadequately activated by TSH receptor antigen, but are normally activated by irrelevant autoantigen. This reduction is partial only, and insufficient itself to precipitate the autoimmune disease; further insults from the environment are necessary to further reduce generalized regulatory cell activity, adding to the genetically induced specific regulatory cell dysfunction, which appears in turn to be due to a specific defect in the presentation of a specific antigen. This, in turn, may relate to abnormalities of the genes responsible for antigen presentation. The end result is activation of appropriat...Continue Reading

References

Nov 1, 1979·Diabetes·A A RossiniA A Like
Mar 1, 1977·Revue française de transfusion et immuno-hématologie·G HauptmannS Mayer
Jan 1, 1992·International Archives of Allergy and Immunology·G WickA Aguzzi
Jul 1, 1992·Clinical Immunology and Immunopathology·N TandonA P Weetman
Jan 1, 1992·Thyroid : Official Journal of the American Thyroid Association·A Martin, T F Davies
Jan 15, 1991·Lancet·M HumphreyK D Burman
Jul 6, 1991·Lancet·A P Weetman
Aug 1, 1991·The Journal of Clinical Endocrinology and Metabolism·A MangklabruksL J DeGroot
Jan 1, 1991·Annual Review of Immunology·M L Dustin, T A Springer
Oct 1, 1991·Clinical and Experimental Immunology·N TandonA P Weetman
Jan 1, 1991·Thyroid : Official Journal of the American Thyroid Association·T TominagaS Nagataki
May 1, 1991·The Journal of Endocrinology·R L Kennedy, T H Jones
Feb 1, 1990·Clinical and Experimental Immunology·S M McLachlanB Rees Smith
Apr 1, 1990·Journal of Autoimmunity·A M Krieg, A D Steinberg
May 1, 1985·Clinics in Endocrinology and Metabolism·S Ratanachaiyavong, A M McGregor
Jan 1, 1989·Endocrinology·D S NeufeldT F Davies
Jul 1, 1989·The Journal of Endocrinology·A P WeetmanL K Borysiewicz
Jan 1, 1985·The Journal of Clinical Endocrinology and Metabolism·B Grubeck-LoebensteinW Waldhäusl
Jan 1, 1987·The New England Journal of Medicine·T H TöttermanI Mendel-Hartvig
Sep 1, 1986·The Journal of Clinical Endocrinology and Metabolism·Y IwataniR Volpé
Jan 1, 1988·The Journal of Clinical Endocrinology and Metabolism·P J KabelH A Drexhage
Jan 1, 1987·Acta Endocrinologica. Supplementum·J E DumontM Ludgate
Feb 1, 1986·The Journal of Clinical Endocrinology and Metabolism·J Y Chan, P G Walfish
Jan 1, 1987·The New England Journal of Medicine·R Volpé
Oct 1, 1986·The Australian Journal of Experimental Biology and Medical Science·P Price, P G Holt

❮ Previous
Next ❯

Citations

Jul 15, 2004·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·M Buljan-CvijanovicA Zemtsov

❮ Previous
Next ❯

Related Feeds

Autoimmune Thyroiditis

Autoimmune thyroiditis is an inflammatory disease of thyroid gland due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-cells and thyroid autoantibodies. Discover the latest research on autoimmune thyroiditis here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

© 2022 Meta ULC. All rights reserved