The Pathogenesis of Implant-Related Reactive Lesions: A Clinical, Histologic and Polarized Light Microscopy Study

Journal of Periodontology
Michal Halperin-SternfeldSharon Akrish

Abstract

Peri-implant soft tissue reactive lesions (I-RLs) may jeopardize implant success and survival. To the best of the authors' knowledge, its pathogenesis is unknown. The objective of this study is to conduct a clinicopathologic and polarized light microscopy (PLM) analysis of 14 new I-RLs and compare them with comparable tooth-associated cases (T-RLs) to better understand I-RL pathogenesis. Fifty-eight new cases of I-RL and T-RL were retrieved from the pathology department archives of Rambam Health Care Campus, Haifa, Israel. Retrospective analysis of histopathologic and clinical features was conducted, documented, and then compared for: 1) I-RL (n = 14), 2) peri-implant pyogenic granuloma (I-PG) (n = 5), 3) peri-implant peripheral giant cell granuloma (I-PGCG) (n = 9), 4) T-RL (n = 44), 5) tooth-associated pyogenic granuloma (T-PG) (n = 21), and 6) tooth-associated peripheral giant cell granuloma (T-PGCG) (n = 23). Presence of foreign bodies was assessed using PLM. Foreign bodies were found more commonly in I-RLs (n = 13/14; 93%) when compared with T-RLs (n = 18/44; 41%), which was a statistically significant difference (P = 0.01) with an odds ratio of 7.9. Microscopically, I-PGCG was associated with: 1) lower multinucleated gian...Continue Reading

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Citations

Sep 6, 2017·The Journal of Oral Implantology·Fotios BountaniotisIoannis Melakopoulos
Oct 12, 2018·Clinical Oral Implants Research·Andrea MombelliNorbert Cionca
Jan 6, 2018·The Journal of Craniofacial Surgery·Antonio ScaranoGianfranco Favia
Jul 31, 2020·Journal of Periodontology·Thomas G Wilson
Oct 4, 2018·Clinical Oral Implants Research·Fernando Suárez-López Del AmoCristiane H Squarize
Feb 6, 2021·Oral Diseases·María Luisa PaparellaDaniel Gustavo Olmedo

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