PMID: 3445354Jan 1, 1987

The pathogenesis of Japanese encephalitis virus in Culex tritaeniorhynchus mosquitoes

Transactions of the Royal Society of Tropical Medicine and Hygiene
C J Leake, R T Johnson


Culex tritaeniorhynchus were inoculated intrathoracically with mosquito and human strains of Japanese encephalitis virus and maintained at 26 degrees C or 32 degrees C. Virus titration and localization of viral antigen by avidin-biotin immunoperoxidase staining were done at intervals up to 21 days. Marked differences were noted in the tempo of organ involvement at the 2 temperatures; at both there was initial infection of fat body cells followed by selective infection of the central nervous system (CNS), with consistent infection of cells of the compound eye, patchy involvement of cephalic, thoracic and abdominal ganglia and no infection of Johnston's organ. CNS infection was always present 4 days after infection, when salivary gland involvement was first seen at 32 degrees C; at 26 degrees C CNS infection preceded salivary gland infection by 2 weeks. Late involvement of gut cells, pericardial cells and oviducts was also found, with no involvement of muscle.


Apr 1, 1992·Parasitology Today·C J Leake
Jul 2, 2004·Vector Borne and Zoonotic Diseases·Yvette A GirardStephen Higgs
Jan 1, 1996·Medical and Veterinary Entomology·K J LinthicumD W Vaughn
Sep 7, 2013·PLoS Neglected Tropical Diseases·Amy J SchuhAlan D T Barrett
Jan 1, 2007·Journal of Insect Science·Joel J L LutomiahRosemary C Sang
Aug 29, 2012·The American Journal of Tropical Medicine and Hygiene·Nicole NemethRichard Bowen
Dec 1, 1988·Molecular and Cellular Probes·M E BallingerB R Miller
Aug 9, 2006·Journal of Medical Entomology·Kun-Hsien TsaiWei-June Chen
Mar 11, 2006·Clinical Science·Tongguang WangAvindra Nath
Jun 8, 2018·Frontiers in Microbiology·Hong-Wai ThamMiaw-Fang Chew


Jan 1, 1976·The American Journal of Tropical Medicine and Hygiene·D Gubler, L Rosen
Jan 1, 1979·The American Journal of Tropical Medicine and Hygiene·M Takahashi, K Suzuki
Apr 25, 1973·Journal of Medical Entomology·J A MilesT Maguire
Nov 1, 1974·The American Journal of Tropical Medicine and Hygiene·L Rosen, D Gubler
Jan 1, 1983·Annual Review of Entomology·J L HardyW C Reeves
Jan 1, 1983·Advances in Virus Research·P R Grimstad
Apr 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M HsuH Fanger

Related Concepts

Establishment and Maintenance of Localization
Pathogenic Aspects
Animal Oviduct
Pericardial Sac Structure
Dissecting Aneurysm of the Thoracic Aorta
Japanese Encephalitis
Salivary Gland Infection

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