PMID: 6414086Aug 1, 1983Paper

The pathogenesis of rheumatoid arthritis and the immune response

Seminars in Arthritis and Rheumatism
M A Scheinberg

Abstract

The interrelationship among lymphocytes, macrophages, and neutrophils appears to be an important aspect of the synovial inflammation that is characteristic of rheumatoid arthritis. In a study comparing gold sodium aurothiomalate (GST) with auranofin (Au), an orally absorbed compound, both appeared to inhibit the disease process and no difference between parenteral and oral administration was observed. Another study involved two groups of nine patients with severe rheumatoid arthritis. One group underwent plasmapheresis. The second group underwent total lymphoid irradiation. Both agents appeared to inhibit the disease process. Plasmapheresis was better tolerated that irradiation.

References

Jan 1, 1979·The Journal of Clinical Investigation·P Stastny, C W Fink
Jun 1, 1976·Annals of the Rheumatic Diseases·A E FinkelsteinA Misher
Mar 1, 1977·The Journal of Clinical Investigation·P E Lipsky, M Ziff
Nov 19, 1981·The New England Journal of Medicine·G TosatoR M Blaese

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Citations

Jan 1, 1991·Scandinavian Journal of Rheumatology·A LinosP Kaklamanis
Jan 1, 1986·British Journal of Clinical Pharmacology·J G MartinezM A Scheinberg
Mar 1, 1985·Clinical Rheumatology·H A Rueda, M A Scheinberg
Oct 7, 1998·The Australian & New Zealand Journal of Obstetrics & Gynaecology·M S Mustafa, A H Shamina
Feb 1, 1997·The International Journal of Neuroscience·J M ArceneauxR S Dean

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