PMID: 8938846Nov 1, 1996Paper

The pathogenic role of pulmonary intravascular macrophages in acute African swine fever

Research in Veterinary Science
L CarrascoM A Sierra

Abstract

Recent studies of pulmonary intravascular macrophages have led to the re-examination of the mechanisms giving rise to alveolar oedema. A highly virulent isolate of African swine fever virus was replicated in pulmonary intravascular macrophages, interstitial and alveolar macrophages, fibroblasts and neutrophils. The alveolar oedema-characteristic of acute forms of African swine fever-and the vascular changes observed, which consisted of the formation of fibrin microthrombi in septal capillaries and the vacuolisation of endothelial cells, may have been due, however, to the activation of pulmonary intravascular macrophages, and not to the cytopathic effect subsequent to the replication of the African swine fever virus. Furthermore, it was observed that virus replication in cells not belonging to the mononuclear phagocyte system-such as fibroblasts and neutrophils-occurred earlier than in cells belonging to that system.

References

Aug 1, 1992·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·A FernandezM A Sierra
Jan 1, 1992·Journal of Veterinary Internal Medicine·L O WhiteleyM S Kannan
Feb 1, 1988·Virus Research·I C PanM Shimizu
Oct 1, 1988·The American Review of Respiratory Disease·T A BertramA R Brody
Sep 1, 1995·The Journal of General Virology·J C Gómez-VillamandosM A Sierra
Oct 1, 1995·Virology·R DuncanR R Mirkovic
Feb 1, 1993·The Tohoku Journal of Experimental Medicine·S SuzukiS Fujimura
Jan 1, 1993·Archives of Virology·C J VilledaE Viñuela
Jun 1, 1993·Research in Immunology·G E Grau, J Lou
Sep 1, 1995·Research in Veterinary Science·J C Gómez-VillamandosP J Wilkonson

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Citations

Feb 5, 2013·Virus Research·J C Gómez-VillamandosL Carrasco
Nov 10, 2012·Virus Research·Sandra BlomeMartin Beer
Oct 30, 2004·Journal of Comparative Pathology·L CarrascoJ C Gómez-Villamandos
Dec 3, 2014·Journal of Comparative Pathology·J M Sánchez-VizcaínoL Carrasco
Oct 3, 2000·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·M QuezadaM A Sierra
Jun 9, 2020·Frontiers in Veterinary Science·Francisco J Salguero
Sep 27, 2020·Transboundary and Emerging Diseases·Uda Zahli IzzatiRyoji Yamaguchi
Dec 8, 2020·Veterinary World·Sharanagouda S PatilParimal Roy
Aug 27, 2021·Veterinary Sciences·Georgia D BrellouEleni D Tzika

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