The pathogenicity island-associated K15 capsule determinant exhibits a novel genetic structure and correlates with virulence in uropathogenic Escherichia coli strain 536

Infection and Immunity
György SchneiderJörg Hacker

Abstract

The K15 capsule determinant of uropathogenic Escherichia coli strain 536 (O6:K15:H31) is part of a novel 79.6-kb pathogenicity island (PAI) designated PAI V536 that is absent from the genome of nonpathogenic E. coli K-12 strain MG1655. PAI V536 shows typical characteristics of a composite PAI that is associated with the pheV tRNA gene and contains the pix fimbriae determinant as well as genes coding for a putative phosphoglycerate transport system, an autotransporter protein, and hypothetical open reading frames. A gene cluster coding for a putative general secretion pathway system, together with a kps(K15) determinant, is localized downstream of a truncated pheV gene ('pheV) also present in this chromosomal region. The distribution of genes present on PAI V536 was studied by PCR in different pathogenic and nonpathogenic E. coli isolates of various sources. Analysis of the 20-kb kps locus revealed a so far unknown genetic organization. Generally, the kps(K15) gene cluster resembles that of group 2 and 3 capsules, where two conserved regions (regions 1 and 3) are located up- or downstream of a highly variable serotype-specific region (region 2). Interestingly, recombination of a group 2 and 3 determinant may have been involved i...Continue Reading

References

Jul 1, 1992·Canadian Journal of Microbiology·K Jann, B Jann
Jan 1, 1990·Current Topics in Microbiology and Immunology·E R Moxon, J S Kroll
Aug 1, 1988·Journal of Clinical Microbiology·T SandbergC Svanborg-Edén
Jan 1, 1985·Current Topics in Microbiology and Immunology·K N TimmisF C Cabello
Jun 1, 1973·The Journal of Infectious Diseases·B Kaijser
Sep 1, 1968·The Journal of Experimental Medicine·D N MedearisE C Heath
Jan 1, 1982·Reviews of Infectious Diseases·M A Horwitz
Jan 1, 1994·The Journal of Infectious Diseases·T A RussoA S Cross
Jan 1, 1993·Advances in Microbial Physiology·C Whitfield, M A Valvano
Jan 1, 1996·Annual Review of Microbiology·I S Roberts
Oct 15, 1996·Nucleic Acids Research·P J OefnerR W Davis
Sep 1, 1997·Nucleic Acids Research·S F AltschulD J Lipman
Apr 14, 1999·Molecular Microbiology·C Whitfield, I S Roberts
Jun 1, 2000·Proceedings of the National Academy of Sciences of the United States of America·K A Datsenko, B L Wanner
Feb 13, 2001·Microbial Pathogenesis·K Al-HasaniH Sakellaris
Feb 24, 2001·Nature·N T PernaF R Blattner
Jun 26, 2001·Research in Microbiology·C F Higgins
Jul 16, 2002·Infection and Immunity·Gábor NagyLevente Emödy

❮ Previous
Next ❯

Citations

May 7, 2010·Medical Microbiology and Immunology·Ulrich DobrindtJ Hacker
Jun 15, 2006·Functional & Integrative Genomics·Tim T BinnewiesDavid W Ussery
May 13, 2009·The Journal of Infectious Diseases·Eric L BucklesMichael S Donnenberg
Jan 19, 2010·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Scott MannYi-Ping Phoebe Chen
Jan 16, 2007·Applied and Environmental Microbiology·Concetta RestieriCharles M Dozois
May 23, 2012·Infection and Immunity·Vanessa Martinez-JéhanneChantal Le Bouguénec
Dec 22, 2005·Infection and Immunity·Subhashinie KariyawasamLisa K Nolan
Sep 12, 2006·Journal of Bacteriology·Hanni WillenbrockDavid W Ussery
Feb 3, 2006·Journal of Bacteriology·Christophe BeloinUlrich Dobrindt
Oct 24, 2008·Journal of Clinical Microbiology·James R JohnsonEric Oswald
Sep 24, 2010·PloS One·Sylvie MiquelArlette Darfeuille-Michaud
Aug 17, 2006·Proceedings of the National Academy of Sciences of the United States of America·Elzbieta BrzuszkiewiczUlrich Dobrindt
May 13, 2014·Nature Materials·E Peter MagennisCameron Alexander
Jun 1, 2010·International Journal of Medical Microbiology : IJMM·Jérôme TourretErick Denamur
Oct 20, 2006·International Journal of Medical Microbiology : IJMM·Jana HejnovaCarmen Buchrieser
Aug 2, 2006·Molecular Microbiology·Janet M Manson, Michael S Gilmore
Sep 15, 2009·Genomics·Scott Mann, Yi-Ping Phoebe Chen
Mar 13, 2014·FEMS Microbiology Letters·Helen Miajlovic, Stephen G Smith
Aug 3, 2006·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M SabatéG Prats
Nov 18, 2008·Molecular and Cellular Endocrinology·Sudhanshu BhushanAndreas Meinhardt
Nov 5, 2017·Applied and Environmental Microbiology·Michael A OlsonDavid L Erickson
Jul 30, 2020·Scientific Reports·Hugo F AzurmendiWillie F Vann
May 10, 2017·BMC Genomics·Andreas LeimbachUlrich Dobrindt
Feb 4, 2021·International Journal of Molecular Sciences·Marta KsiążczykGabriela Bugla-Płoskońska
Aug 1, 2009·EcoSal Plus·Chris Whitfield
Aug 1, 2009·EcoSal Plus·Harry L T MobleyErin C Hagan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

CRISPR & Staphylococcus

CRISPR-Cas system enables the editing of genes to create or correct mutations. Staphylococci are associated with life-threatening infections in hospitals, as well as the community. Here is the latest research on how CRISPR-Cas system can be used for treatment of Staphylococcal infections.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.