The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice.

Nature
Linlin BaoChuan Qin

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of coronavirus disease 2019 (COVID-19), which has become a public health emergency of international concern1. Angiotensin-converting enzyme 2 (ACE2) is the cell-entry receptor for severe acute respiratory syndrome coronavirus (SARS-CoV)2. Here we infected transgenic mice that express human ACE2 (hereafter, hACE2 mice) with SARS-CoV-2 and studied the pathogenicity of the virus. We observed weight loss as well as virus replication in the lungs of hACE2 mice infected with SARS-CoV-2. The typical histopathology was interstitial pneumonia with infiltration of considerable numbers of macrophages and lymphocytes into the alveolar interstitium, and the accumulation of macrophages in alveolar cavities. We observed viral antigens in bronchial epithelial cells, macrophages and alveolar epithelia. These phenomena were not found in wild-type mice infected with SARS-CoV-2. Notably, we have confirmed the pathogenicity of SARS-CoV-2 in hACE2 mice. This mouse model of SARS-CoV-2 infection will be valuable for evaluating antiviral therapeutic agents and vaccines, as well as understanding the pathogenesis of COVID-19.

References

Jan 1, 1937·Journal of Bacteriology·T M Rivers
Jun 28, 2016·Nature Reviews. Microbiology·Emmie de WitVincent J Munster
Jan 25, 2020·The New England Journal of Medicine·Na ZhuUNKNOWN China Novel Coronavirus Investigating and Research Team
Jun 24, 2020·Biosafety and Health· National Health Commission Of The People's Republic Of China

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Citations

Jun 24, 2020·Microbial Biotechnology·Harald Brüssow
May 22, 2020·European Journal of Immunology·Huibin LvChris K P Mok
Jul 8, 2020·Pathogens·Ahmed S Abdel-Moneim, Elsayed M Abdelwhab
Jul 4, 2020·Journal of Medical Virology·Satarudra Prakash SinghThakur Prasad Yadav
May 15, 2020·Nature·Sin Fun SiaHui-Ling Yen
Jul 13, 2020·Transboundary and Emerging Diseases·Claude SaegermanMarie-France Humblet
Jul 17, 2020·Clinical and Experimental Immunology·D BakerS Amor
Aug 5, 2020·The Journal of Experimental Medicine·Benjamin IsraelowAkiko Iwasaki
Jul 15, 2020·Nature Nanotechnology·Helena F FlorindoRonit Satchi-Fainaro
Jun 28, 2020·Journal of Virology·John P Moore, P J Klasse
May 23, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ankit B Patel, Ashish Verma
Apr 3, 2020·Stroke; a Journal of Cerebral Circulation
Aug 7, 2020·Médecine sciences : M/S·Sara Salinas, Yannick Simonin
Aug 2, 2020·The FEBS Journal·Pu Xia, Anna Dubrovska
Jul 15, 2020·Journal of Virology·Xuesen ZhaoHanxin Lin
Aug 28, 2020·Open Biology·Vanessa WaznyChristine Cheung
Jul 30, 2020·The American Journal of Tropical Medicine and Hygiene·Gregory Brett MoreauBarbara J Mann
Aug 25, 2020·Cellular and Molecular Bioengineering·Jhinuk Basu MullickJanak Gaire
Sep 12, 2020·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Rafal Butowt, Christopher S von Bartheld
Sep 15, 2020·The Journal of Experimental Medicine·Coraline RadermeckerThomas Marichal
Sep 15, 2020·Journal of Basic and Clinical Physiology and Pharmacology·Anupama M Gudadappanavar, Jyoti Benni
Sep 9, 2020·Emerging Microbes & Infections·Tingting LiNingshao Xia
Sep 29, 2020·Scientific Reports·Greg N Brooke, Filippo Prischi
May 22, 2020·Journal of Translational Internal Medicine·Mengyuan LiuJianping Li
Sep 24, 2020·Nature·Florian Krammer
Jul 3, 2020·The Indian Journal of Medical Research·Sreelekshmy MohandasRaman R Gangakhedkar
Jul 3, 2020·Frontiers in Neuroanatomy·Marcos F DosSantosVivaldo Moura-Neto
Aug 21, 2020·Signal Transduction and Targeted Therapy·Shuaiyao LuXiaozhong Peng
Sep 10, 2020·Journal of the Chinese Medical Association : JCMA·Yu-Ju LaiCheng-Chang Chang
Aug 21, 2020·Mucosal Immunology·M D JohansenP M Hansbro
Jul 3, 2020·Animal Models and Experimental Medicine·Cynthia Pekow
Jul 24, 2020·Viruses·Nikolaus OsterriederJakob Trimpert
Sep 19, 2020·Journal of Cellular Physiology·Rajasekaran MahalingamRajarajan A Thandavarayan

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Datasets Mentioned

BETA
MDC60013002-01

Methods Mentioned

BETA
transgenic
electron microscopy
enzyme-linked immunosorbent assay
PCR
ELISA
light microscopy
fluorescence microscopy
transmission electron microscopy

Software Mentioned

DNAStar
DNAMAN

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