The pathologic role for COX-2 in apoptotic oligodendrocytes in virus induced demyelinating disease: implications for multiple sclerosis

Journal of Neuroimmunology
Noel G CarlsonJohn W Rose

Abstract

The objective of this study was examine whether the inducible isoform of the enzyme cyclooxygenase (COX-2) was expressed in dying oligodendrocytes in the Theiler's murine encephalomyelitis virus (TMEV) induced demyelinating disease (TMEV-IDD), an experimental animal model for multiple sclerosis (MS). COX-2 is an enzyme that is tightly coupled to neuronal excitotoxic death. Since neuronal expression of COX-2 contributes to the susceptibility of neurons to excitotoxic death, we asked whether COX-2 was expressed in oligodendrocytes in MS plaques and in lesions during TMEV-IDD. COX-2 was expressed in oligodendrocytes in chronic active lesions from two MS patients. Similar pathology was present in TMEV-IDD spinal cord lesions. COX-2 was expressed in oligodendrocytes four weeks after infection with TMEV coincident with the onset of demyelination. A marker for apoptotic death, activated caspase 3, was present in a subset of oligodendrocytes that expressed COX-2. Oligodendrocyte expression of COX-2 in TMEV-IDD and MS lesions is consistent with a pathological role for this enzyme in demyelination. The presence of the cell death marker (activated caspase 3) with COX-2 in oligodendrocytes is direct evidence linking COX-2 with cell death o...Continue Reading

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Citations

Jun 15, 2011·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Samir S AyoubChristopher Bolton
Nov 7, 2009·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Ikuo Tsunoda, Robert S Fujinami
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May 23, 2015·Journal of Neuroinflammation·Noel G CarlsonJohn W Rose
Sep 7, 2017·Scientific Reports·Fumitaka SatoIkuo Tsunoda
Dec 1, 2009·Neurobiology of Disease·Brian A FallonDavid Hardesty

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