The pathological effects of immunosuppression of Schistosoma mansoni-infected mice, with particular reference to survival and hepatotoxicity after thymectomy and treatment with antithymocyte serum, and treatment with hydrocortisone acetate

Transactions of the Royal Society of Tropical Medicine and Hygiene
S LucasM J Doenhoff

Abstract

The effects of various immunosuppressive regimes on the survival and liver pathology of mice infected with Schistosoma mansoni were investigated. T-cell deprivation before infection (by adult thymectomy and subsequent anti-thymocyte serum administration), or treatment with hydrocortisone or cyclophosphamide or azathioprine after infection, all reduced survival of infected mice when compared with immunologically intact, infected mice. T-cell deprivation or steroids produced severe liver damage in infected mice despite a reduction in the size of the peri-oval granulomatous inflammatory reaction. Administration of chronic infection serum reduced liver damage in both T-cell-deprived and steroid-treated animals, but improved survival only in the deprived animals and not to the level seen in normal infected mice. The liver damage in immunosuppressed mice was not due to opportunistic bacterial infection. Thus, although immunosuppression reduced the granulomatous response to schistosome eggs in the livers of infected mice (as it does to eggs injected intravenously into the lungs), survival time was decreased. The relevance of these findings to human S. mansoni infections is discussed.

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Citations

Jan 1, 1984·European Journal of Clinical Pharmacology·N OdumI C Bygbjerg
Jan 1, 1984·Transactions of the Royal Society of Tropical Medicine and Hygiene·D W DunneM J Doenhoff
Jan 1, 1986·Transactions of the Royal Society of Tropical Medicine and Hygiene·M J DoenhoffS Lucas
Dec 1, 1988·Molecular and Biochemical Parasitology·M J DoenhoffG O Adeoye
Apr 17, 2003·Trends in Immunology·Michael J Doenhoff
May 6, 1998·Parasite Immunology·A Viana da CostaJ M Grzych
Dec 18, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Stan HoustonKen Warren
Dec 16, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S de SilvaM Brown
Mar 5, 2009·The Journal of Clinical Investigation·Justin J TaylorEdward J Pearce
Nov 1, 2011·PLoS Neglected Tropical Diseases·Maha-Hamadien AbdullaConor R Caffrey
Oct 18, 2006·Parasite Immunology·W E Secor
Jul 1, 1989·Parasite Immunology·A M AgnewM J Doenhoff
Apr 1, 1985·Australian and New Zealand Journal of Medicine·C M Mukerjee, D K McKenzie
Mar 1, 1995·Revista Do Instituto De Medicina Tropical De São Paulo·S M TonelliP M Coelho
Oct 16, 2004·Memórias do Instituto Oswaldo Cruz·W Evan SecorDaniel G Colley
Jul 1, 1996·Revista Do Instituto De Medicina Tropical De São Paulo·P M CoelhoR Gonçalves
Sep 17, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Keke C FairfaxEdward J Pearce
Dec 1, 1987·Parasitology·H M MurareM J Doenhoff
Nov 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christophe ChevillardAlain J Dessein
Sep 7, 2005·Molecular and Biochemical Parasitology·Colin M FitzsimmonsDavid W Dunne

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