The pathophysiologic role of monocytes and macrophages in systemic lupus erythematosus: a reappraisal

Seminars in Arthritis and Rheumatism
Christina G KatsiariPetros P Sfikakis

Abstract

To review current developments, regarding the pathophysiologic role of monocytes and macrophages in systemic lupus erythematosus (SLE). We searched Medline for articles written in the English language using the following terms: monocyte(s) or macrophage(s) and lupus. Although our search spanned the years 1971 to 2008, the majority of the short-listed articles belonged to the period 2000 to 2008. Published literature on phenotypic and functional properties of monocytes/macrophages (Mo/Mphi) in SLE was reviewed. References from identified articles were also selected. Currently available experimental data and their relevance to the pathogenesis of SLE are critically discussed. It has traditionally been held that impaired phagocytosis by monocytes and macrophages in SLE allows for the accumulation of apoptotic debris leading to a sequel of autoimmune phenomena. Recent paradigms derived from animal models of systemic autoimmunity, however, has broadened our understanding regarding the possible pathophysiologic roles of Mo/Mphi in SLE. Data derived from studies in patients with SLE show multiple aberrations in activation status and secretory functions of circulating and tissue-infiltrating Mo/Mphi. Such aberrations may be associated ...Continue Reading

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Citations

Mar 26, 2014·International Journal of Molecular Sciences·Fa-Yan MengXue-Hua Li
Jun 16, 2012·Clinical & Developmental Immunology·Yi-Wen JiangDao-Feng Chen
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