Histological and electrophysiological studies were performed on Lewis rats with acute experimental allergic encephalomyelitis (EAE) induced by inoculation with guinea-pig spinal cord and Freund's adjuvants, in order to determine the cause of the neurological signs. These studies demonstrated demyelination-induced nerve conduction block in the large and also the smaller diameter fibres at the ventral root exit zone (VREZ) of the lumbar spinal cord. The demyelination at the VREZ affected both centrally and peripherally myelinated internodes, but predominantly the former. Studies on the H reflex recorded from a hindfoot muscle indicated normal peripheral nerve motor conduction but interruption of the monosynaptic reflex arc, as would be anticipated from this efferent conduction block and previously reported afferent conduction abnormalities. It is concluded that conduction block in alpha, beta and gamma motor fibres at the VREZ is an important cause of hindlimb weakness in whole spinal cord-induced acute EAE.
Lack of suppressive effect of alpha-foetoprotein on development of experimental allergic encephalomyelitis in rats
Failure of 5-hydroxytryptophan to increase lumbar MSR amplitude in rats paralyzed with experimental allergic encephalomyelitis.
Chronic relapsing experimental allergic encephalomyelitis: effect of age at the time of sensitization on clinical course and pathology
The internodal axon membrane: electrical excitability and continuous conduction in segmental demyelination
Concomitant detection of changes in myelin basic protein and permeability of blood-spinal cord barrier in acute experimental autoimmune encephalomyelitis by electroimmunoblotting
Conduction block due to demyelination at the ventral root exit zone in experimental allergic encephalomyelitis
Involvement of the dorsal root ganglion in acute experimental allergic encephalomyelitis in the Lewis rat. A histological and electrophysiological study
Axo-glial relations in the retina-optic nerve junction of the adult rat: electron-microscopic observations
Properties, structure and possible neuroreceptor role of the encephalitogenic protein of human brain
Mechanism of demyelination in allergic encephalomyelitis of guinea pigs. An electron microscopic study
Hind-limb motor ability in Lewis rats during the onset and recovery phases of experimental autoimmune encephalomyelitis
Restoration of conduction in the spinal roots correlates with clinical recovery from experimental autoimmune encephalomyelitis
The pathophysiology of myelin basic protein-induced acute experimental allergic encephalomyelitis in the Lewis rat.
Hypothermia due to an ascending impairment of shivering in hyperacute experimental allergic encephalomyelitis in the Lewis rat
Clinical and histological findings in proteolipid protein-induced experimental autoimmune encephalomyelitis (EAE) in the Lewis rat. Distribution of demyelination differs from that in EAE induced by other antigens
T-cell receptor V beta-element expression in peripheral nerves of Lewis rats suffering from experimental autoimmune neuritis
Conduction properties of central demyelinated and remyelinated axons, and their relation to symptom production in demyelinating disorders
The pathophysiology of multiple sclerosis: the mechanisms underlying the production of symptoms and the natural history of the disease
Changes in brain and spinal cord water content during recurrent experimental autoimmune encephalomyelitis in female Lewis rats
Motor neuron destruction in guinea pigs immunized with bovine spinal cord ventral horn homogenate: experimental autoimmune gray matter disease
Demyelination and early remyelination in experimental allergic encephalomyelitis passively transferred with myelin basic protein-sensitized lymphocytes in the Lewis rat.
Characterisation of sensory abnormalities observed in an animal model of multiple sclerosis: a behavioural and pharmacological study
Chronic remitting experimental allergic encephalomyelitis in Lewis rats as a model of multiple sclerosis
Cardiac Conduction System
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