May 20, 2020

The Pathophysiology of Degenerative Cervical Myelopathy and the Physiology of Recovery Following Decompression

Frontiers in Neuroscience
Farhana AkterMark Kotter

Abstract

Background: Degenerative cervical myelopathy (DCM), also known as cervical spondylotic myelopathy is the leading cause of spinal cord compression in adults. The mainstay of treatment is surgical decompression, which leads to partial recovery of symptoms, however, long term prognosis of the condition remains poor. Despite advances in treatment methods, the underlying pathobiology is not well-known. A better understanding of the disease is therefore required for the development of treatments to improve outcomes following surgery. Objective: To systematically evaluate the pathophysiology of DCM and the mechanism underlying recovery following decompression. Methods: A total of 13,808 published articles were identified in our systematic search of electronic databases (PUBMED, WEB OF SCIENCE). A total of 51 studies investigating the secondary injury mechanisms of DCM or physiology of recovery in animal models of disease underwent comprehensive review. Results: Forty-seven studies addressed the pathophysiology of DCM. Majority of the studies demonstrated evidence of neuronal loss following spinal cord compression. A number of studies provided further details of structural changes in neurons such as myelin damage and axon degeneration....Continue Reading

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Mentioned in this Paper

Traumatic Injury
Research Personnel
Physiology
Operative Surgical Procedures
Cell Plasticity
Myelin Proteins
Recovery - Healing Process
Study
Worse
Spinal Cord

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