The pathophysiology of failure in acute right ventricular hypertension: hemodynamic and biochemical correlations

Circulation
G J VlahakesJ I Hoffman

Abstract

Acute right ventricular (RV) hypertension and failure occur clinically. In this study we examined the mechanism of RV failure. Adult dogs were studied acutely under anesthesia; dogs were instrumented for measurement of pressures and right coronary artery blood flow. Myocardial blood flow and cardiac output were determined with radionuclide-labeled microspheres, and the presence of ischemia was determined by biochemical analysis of ventricular biopsies. RV hypertension was produced by constricting the pulmonary artery and was increased until RV failure occurred, as evidenced by decreased aortic pressure and cardiac output and increased RV end-diastolic pressure. With increasing RV systolic pressure, RV myocardial blood flow failed to increase in proportion to demand. At the onset of RV failure, there was no reactive hyperemia of right coronary flow compared with control, indicating the absence of further coronary vascular reserve; biochemical analysis demonstrated that the RV free wall was ischemic; the LV free wall was not. Infusion of phenylephrine raised aortic pressure and hence, myocardial perfusion pressure; RV failure reversed as shown by decreased RV end-diastolic pressure and increased cardiac output and RV systolic pre...Continue Reading

References

Apr 1, 1976·European Journal of Pharmacology·S C Verma, J H McNeill
Mar 1, 1978·Circulation Research·R A OlssonM K Gentry
Jul 1, 1977·Progress in Cardiovascular Diseases·M A HeymannA M Rudolph
Mar 1, 1975·Anesthesiology·G W OstheimerE Lowenstein
Nov 1, 1973·Cardiovascular Research·C B HigginsS F Vatner
Apr 1, 1974·The American Journal of Physiology·G ElzingaG C van den Bos
Jun 1, 1974·The American Journal of Cardiology·E W StoolJ H Mitchell
Feb 1, 1968·American Heart Journal·K B CairnsH E Griswold
Oct 1, 1971·Journal of Applied Physiology·G D BuckbergD E Fixler
Oct 1, 1971·American Heart Journal·H M SpotnitzS E Epstein
Oct 1, 1971·The Journal of Clinical Investigation·H BrooksE H Sonnenblick
Jul 1, 1971·Journal of Applied Physiology·V G Debley
May 1, 1967·Acta Physiologica Scandinavica·K AuklandJ Kjekshus
Dec 1, 1960·The American Journal of Physiology·J D COFFMAN, D E GREGG
Nov 1, 1960·Circulation Research·J P HOLTH KINES
Nov 1, 1960·Circulation Research·S VARMAW B YOUMANS
Oct 1, 1961·The American Journal of Physiology·E S BENSONE F FREIER
Jan 1, 1962·The American Journal of Physiology·C E CROSS

❮ Previous
Next ❯

Citations

Feb 1, 1985·World Journal of Surgery·D J FarrarJ D Hill
Jul 1, 1985·Basic Research in Cardiology·P E LangeP H Heintzen
Jan 1, 1983·Pediatric Cardiology·R JedeikinJ E Gillan
Feb 1, 1997·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·S PietakB Porter
Sep 1, 1986·Canadian Anaesthetists' Society Journal·F A BurrowsD J Bohn
Sep 8, 2010·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Lin PiaoStephen L Archer
Jul 14, 2010·International Journal of Legal Medicine·Tony FracassoAndreas Schmeling
Jun 16, 2010·General Thoracic and Cardiovascular Surgery·Daijiro HoriHideo Adachi
May 29, 2009·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Andrew MaslowPaul M Heerdt
Jan 1, 1989·The Annals of Thoracic Surgery·D M RoseF C Spencer
Feb 1, 1996·The Annals of Thoracic Surgery·D A FullertonF L Grover
Feb 1, 1990·Prostaglandins·J Y TsangR R Schellenberg
Nov 26, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Piotr PruszczykHanna Berent
Jul 8, 1998·Pediatric Clinics of North America·L D Nelin, G M Hoffman
Feb 5, 1998·Progress in Cardiovascular Diseases·W P Santamore, L J Dell'Italia
Jun 1, 1983·Journal of the American College of Cardiology·A GarsonD G McNamara
Apr 1, 1985·Journal of the American College of Cardiology·R W SmallingD J Fisher
May 1, 1996·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·D S Schulman
Feb 11, 1993·The New England Journal of Medicine·R RossaintW M Zapol
Apr 13, 1999·Critical Care Medicine·A MercatH Sors
Oct 5, 2001·Current Opinion in Pulmonary Medicine·J D Douketis
Oct 3, 2002·Current Opinion in Critical Care·Sreenandh KrishnagopalanAnand Kumar
Apr 9, 2004·Critical Care Medicine·François KerbaulSerge Brimioulle
Sep 15, 2006·Critical Care Medicine·François KerbaulSerge Brimioulle
Jun 15, 2007·Critical Care Medicine·François KerbaulFrédéric Collart
Feb 15, 2008·Critical Care Medicine·Clifford R Greyson
Jul 22, 2009·Journal of Cardiovascular Pharmacology·John A WattsJeffrey A Kline
May 15, 2012·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Begum AkayKeith E Cook
May 20, 2009·Current Opinion in Critical Care·Antoine Vieillard-Baron
Feb 15, 2011·American Journal of Therapeutics·Ankur KalraSergio L Zanotti-Cavazzoni
Mar 20, 2010·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Avinash C Shukla, Melvin C Almodovar
Jan 1, 1991·Acta Anaesthesiologica Scandinavica. Supplementum·P Foëx
Nov 1, 1996·Zentralblatt für Veterinärmedizin. Reihe A·B SustronckE Muylle
Feb 15, 2001·Echocardiography·Ary Ribeiro

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.