The pathophysiology of malarial anaemia: where have all the red cells gone?

BMC Medicine
Oscar Kai, David J Roberts

Abstract

Malarial anaemia is an enormous public health problem in endemic areas and occurs predominantly in children in the first 3 years of life. Anaemia is due to both a great increase in clearance of uninfected cells and a failure of an adequate bone marrow response. Odhiambo, Stoute and colleagues show how the age distribution of malarial anaemia and the haemolysis of red blood cells may be linked by an age-dependent increase in the capacity of red blood cells to inactivate complement components absorbed or deposited directly on to the surface of the red blood cell. In this commentary, we discuss what has been established about the role of complement deposition on the surface of red blood cells in the pathology of malarial anaemia, how genetic polymorphisms of the complement control proteins influence the outcome of malaria infection and how the findings of Odhiambo, Stoute and colleagues and others shed light on the puzzling age distribution of different syndromes of severe malaria.

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Citations

Apr 23, 2009·Current Opinion in Hematology·Pierre A BuffetPeter H David
Jun 8, 2011·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Kathryn Maitland
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Dec 3, 2014·Microbial Pathogenesis·Laura Mac-Daniel, Robert Ménard
Oct 9, 2014·The American Journal of Tropical Medicine and Hygiene·Jeong-Hwan Hwang, Chang-Seop Lee
Apr 2, 2019·Frontiers in Endocrinology·Johanna SeitzUdo Rudolf Markert
Aug 7, 2019·Scientific Reports·Isidoros PapaioannouPenelope Vounatsou
Feb 4, 2021·Parasitology Research·Sana AqeelWajihullah Khan
Feb 21, 2021·Nature Communications·Elya DekelNeta Regev-Rudzki

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