PMID: 2503028May 1, 1989Paper

The pathophysiology of peri- and postmenopausal bone loss

British Journal of Obstetrics and Gynaecology
L Nilas, C Christiansen

Abstract

Changes in sex hormones and bone turnover were studied longitudinally in 31 women aged 47-54 years who were approaching the menopause. Every 6 weeks for 2-3 years, hormones and biochemical estimates of the bone turnover were determined and the bone mass was measured at two forearm sites by single photon absorptiometry. Spinal bone mass was measured every 6 months. The bone turnover was normal in women aged 47-54 years with regular menstruation, whereas the estimates of bone resorption were high in the women with irregular menstruation. In nine women, who reached the menopause during the study, bone resorption increased significantly, whereas bone formation showed only a small increase. When the results of the nine women were combined with those of 50 women, who had passed a natural menopause within the preceding 3.5 years, the bone resorption indices reached their peak within the first postmenopausal year, whereas bone formation increased until 1.5-2 years after the last menstrual cycle. At the ultradistal forearm site the rate of bone loss was maximal (5% per year) immediately after the menopause and subsequently declined, which suggests that trabecular bone is more sensitive than cortical bone to changes in bone turnover. Spi...Continue Reading

References

Jan 1, 1979·International Urology and Nephrology·M Csellár, A Csontai
Jan 1, 1979·Journal of Biosocial Science·M G Metcalf
Apr 1, 1975·The Journal of Clinical Investigation·B M Sherman, S G Korenman
Oct 1, 1988·European Journal of Clinical Investigation·L Nilas, C Christiansen
Mar 1, 1987·Acta Endocrinologica·J S JohansenC Christiansen
Nov 1, 1987·The Journal of Clinical Investigation·C SlemendaC C Johnston
Oct 1, 1987·The Journal of Clinical Endocrinology and Metabolism·L Nilas, C Christiansen
Nov 1, 1985·The Journal of Clinical Endocrinology and Metabolism·C C JohnstonC Longcope
Sep 15, 1984·Clinica Chimica Acta; International Journal of Clinical Chemistry·J PødenphantC Christiansen
Nov 15, 1984·The New England Journal of Medicine·L S RichelsonB L Riggs
Mar 1, 1981·Clinical Endocrinology·M G MetcalfJ H Livesey
Feb 1, 1980·The Journal of Clinical Endocrinology and Metabolism·D T BaranL V Avioli
Jun 1, 1953·The Journal of Clinical Endocrinology and Metabolism·H S KUPPERMANW FILLER

❮ Previous
Next ❯

Citations

Aug 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R R ReckerD B Kimmel
Oct 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S S ShermanC C Plato
Mar 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P GarneroP D Delmas
Jan 1, 1990·European Journal of Nuclear Medicine·I FogelmanG Blake
Jan 1, 1993·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C HassagerC Christiansen
Jan 1, 1995·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·K BjarnasonC Christiansen
Jul 1, 1992·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M H WalkinshawC R Paterson
Sep 1, 1992·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·T NaessénR Bergström
Jan 1, 1995·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M GambaccianiA R Genazzani
Sep 1, 1997·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·E V CosmiM M Anceschi
Jan 15, 2002·European Journal of Obstetrics, Gynecology, and Reproductive Biology·D PanidisK Stergiopoulos
Jun 8, 2001·Maturitas·A R Genazzani, M Gambacciani
Dec 4, 2001·Maturitas·M Gambacciani, A R Genazzani
Jun 24, 2003·Maturitas·Marco GambaccianiAndrea Riccardo Genazzani
Feb 6, 2004·Maturitas·Marco GambaccianiChristian Wüster
Jul 29, 1999·Maturitas·A R Genazzani, M Gambacciani
Jan 26, 1999·Clinical Obstetrics and Gynecology·M P Warren, J Kulak
Jan 27, 2012·Menopause : the Journal of the North American Menopause Society·Hugh S Taylor, Kathleen Ohleth
Nov 1, 1993·Annals of the Rheumatic Diseases·W F LemsJ W Bijlsma
May 1, 1993·Postgraduate Medical Journal·J R GrayC R Paterson
Oct 12, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R ReckerR Heaney
Aug 12, 2004·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·M GambaccianiA R Genazzani
Jan 27, 2004·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Aliya A Khan, Zeba Syed
Dec 1, 1994·Journal of Periodontology·N von WowernG Kollerup
Jun 1, 1996·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·J R GuthrieH G Burger
Sep 1, 1994·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·M MoscariniM Valenti
Jun 1, 1995·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·M GambaccianiA R Genazzani
Jul 27, 2007·Climacteric : the Journal of the International Menopause Society·M GambaccianiA R Genazzani
Aug 13, 2005·Climacteric : the Journal of the International Menopause Society·A R GenazzaniUNKNOWN International Menopause Society Expert Workshop
Aug 3, 1999·British Journal of Obstetrics and Gynaecology·M TakahashiT Inoue
Mar 5, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Claudia S RiedtSue A Shapses
Jul 10, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M A Fernández-SearaF W Wehrli
Feb 24, 2000·São Paulo Medical Journal = Revista Paulista De Medicina·D P PardiniJ G Vieira
Mar 1, 1994·Maturitas·M GambaccianiP Fioretti
Jul 1, 1993·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·T KurabayashiK Tanaka
Oct 14, 2003·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Lih-Yuann ShihTain-Hsiung Chen
Jan 11, 2019·Climacteric : the Journal of the International Menopause Society·M GambaccianiS Lello
Jul 20, 2005·Treatments in Endocrinology·Marco GambaccianiAndrea R Genazzani
Dec 24, 2005·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Riccardo AgostiniVittorio Unfer
Oct 1, 1992·Journal of Gerontological Nursing·M A McMahonJ Schilke

❮ Previous
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