PMID: 9546972Jan 1, 1997Paper

The pathophysiology of peripheral arterial disease: rational targets for drug intervention

Vascular Medicine
J P Cooke

Abstract

The most common cause of peripheral arterial disease (PAD) is atherosclerosis, which begins with an alteration in endothelial biology due to hypercholesterolemia, diabetes mellitus, hypertension, tobacco use, elevated levels of lipoprotein(a) or homocystinemia. With chronic and severe arterial disease, changes begin to occur in the microcirculation, including obstruction at the microvascular level and tissue injury. Based on insights into the vascular biology of PAD, new therapies have been developed and are at various stages of clinical trials. Future pharmacotherapy for PAD will include agents that have one or more of the following attributes; (1) reduce, or even reverse, the progression of atherosclerosis; (2) inhibit plaque rupture; (3) inhibit thrombosis by a novel mechanism; (4) induce angiogenesis; (5) reverse microvascular derangements; (6) affect blood rheology; and (7) enhance skeletal muscle's ability to use available nutrients.

References

Sep 1, 1992·The Journal of Clinical Investigation·J P CookeM E Billingham
Jul 1, 1991·Circulation·V Ralevic, G Burnstock
Feb 20, 1986·The New England Journal of Medicine·R Ross
Dec 1, 1987·The Journal of Clinical Investigation·D G HarrisonD D Heistad
Aug 1, 1995·Current Opinion in Lipidology·V M Maher, B G Brown
Jun 1, 1995·Circulation·P Libby
Aug 1, 1994·Current Opinion in Lipidology·A C Liu, R M Lawn
Jan 1, 1996·Arteriosclerosis, Thrombosis, and Vascular Biology·R C CandipanJ P Cooke
Mar 1, 1996·Journal of the American College of Cardiology·E L MayerK Robinson
Jan 1, 1996·Annual Review of Medicine·K A Hajjar, R L Nachman
Aug 5, 1997·Circulation·P S TsaoJ P Cooke

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Citations

Dec 25, 2002·Medicinal Research Reviews·Alexandra MartinDavid C Sane
Apr 11, 2003·Current Treatment Options in Cardiovascular Medicine·Sergio GeneriniMarco Matucci Cerinic
Mar 27, 2001·Journal of the American Podiatric Medical Association·B RiceR M Dixon
Mar 12, 2003·Critical Reviews in Clinical Laboratory Sciences·Giuseppe Lippi, Giancesare Guidi
Nov 25, 2000·Current Opinion in Rheumatology·A L Herrick

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