PMID: 8940999Dec 1, 1996Paper

The pattern of cell proliferation in neoplastic and nonneoplastic lesions of ulcerative colitis

Cancer
A E NoffsingerC M Fenoglio-Preiser

Abstract

Ulcerative colitis (UC) is a chronic inflammatory disease of the colon characterized by repeated episodes of inflammation and epithelial regeneration. Patients with long-standing UC have an increased risk for the development of dysplasia and subsequent colon carcinoma. Because dysplasia likely results from deregulatec cell proliferation, the authors examined Ki-67 immunoreactivity in tissues from UC patients to examine patterns of proliferation in neoplastic and nonneoplastic lesions. One hundred and eighty-seven specimens were obtained from 41 patients with UC and each lesion evaluated according to the International Classification for Dysplasia in Inflammatory Bowel Disease. All sections were stained with a monoclonal antibody directed against the proliferation marker Ki-67, and evaluated by three observers. Statistically significant differences in the pattern of Ki-67 immunoreactivity were observed between nonneoplastic and neoplastic lesions. In regenerative mucosa, Ki-67 immunoreactivity localized to the bases of the crypts, and the proliferative zone appeared expanded. In dysplasia, Ki-67 staining was prominent in cells in the superficial mucosa, as well as in cells at the crypt bases. In some dysplasias and all invasive c...Continue Reading

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Citations

Apr 4, 2014·World Journal of Gastroenterology : WJG·Aude BressenotLaurent Peyrin-Biroulet
Apr 8, 1999·Molecular Pathology : MP·S N AndersenO P Clausen
Feb 27, 2001·Japanese Journal of Cancer Research : Gann·H TakakuK Hatakeyama
Jan 28, 2003·The American Journal of Pathology·Susan E ErdmanJames G Fox
Apr 5, 2008·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·A TursiF Aiello
Nov 13, 2007·Gastroenterology Clinics of North America·Noam Harpaz
Sep 6, 2006·Gastroenterology Clinics of North America·Robert D Odze
Jul 24, 2002·Gastroenterology Clinics of North America·Marian M Haber
Aug 9, 2001·International Journal of Surgical Pathology·Stefan J. Urbanski, Franz Fogt
Jun 8, 2011·Nature Reviews. Gastroenterology & Hepatology·Sigrun ThorsteinsdottirJakob Benedict Seidelin
Apr 25, 2006·Journal of Clinical Gastroenterology·Antonio TursiFabio Aiello
May 18, 2007·Cell and Tissue Research·Jennifer R O'Hara, Keith A Sharkey
Aug 2, 2007·Diseases of the Colon and Rectum·A BelizonR L Whelan
Apr 23, 2005·Digestive Diseases and Sciences·Irena KirmanOle Haagen Nielsen
Jul 9, 1998·Pathology Oncology Research : POR·G Cserni
Oct 29, 2000·Diseases of the Colon and Rectum·M ShinozakiT Muto
Jun 20, 2012·Applied Immunohistochemistry & Molecular Morphology : AIMM·Gabriel Moises GroismanAlona Meir
Jan 13, 2000·The American Journal of Surgical Pathology·V C PetersenN A Shepherd

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