PMID: 14105215Jan 1, 1964


The Journal of Cell Biology
J German


The sequence in which various regions of the chromosomes of human blood cells complete DNA synthesis in vitro has been studied through the use of H(3)-thymidine labeling and autoradiography. Certain of its aspects have been defined, and these may serve as a basis for comparing the pattern of synthesis in cells of other tissues. In general, the long chromosomes continue replication later than the short ones. Variability of the sequence has been prominent. One pair from Group 13-15 and pair No. 17 complete replication early. In certain other chromosomes, replication is very active late in the S period, e.g. one X of the female cell, the Y of the male cell, two of Group 4-5, two of Group 13-15, the Nos. 16, and the Nos. 18. In the normal human female a striking correlation exists between the late replication of one of the X chromosomes, condensation during the intermitotic period, and presumed genetical inactivation. The pattern of replication characterizes certain chromosomes whose structural features alone are non-distinctive, and it may be useful in studies of cells in which a chromosomal aberration occurs.


Jun 1, 1960·The Journal of Biophysical and Biochemical Cytology·J H TAYLOR
Aug 1, 1962·Experimental Cell Research·M A BENDER, D M PRESCOTT
Sep 1, 1962·Nature·C W GILBERTJ ROWLEY
Feb 1, 1963·The Journal of Cell Biology·A Lima-de-Faria, J REITALU
Jan 1, 1962·Cytogenetics·M W SHAW
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May 1, 1988·Human Genetics·K S ReddyD G Papworth
Jan 1, 1972·Chromosoma·M Gontcharoff, B Rao
Mar 1, 1971·Hippokrates·G Neuhäuser
Jan 1, 1969·Zeitschrift Für Kinderheilkunde·J Keutel, I Dauner
Feb 1, 1967·Developmental Biology·M A Di Berardino, T J King
Mar 1, 1981·Cancer Genetics and Cytogenetics·S A LattH Lazarus
Oct 3, 1964·Nature·D CRANMORE, E L ALPEN
May 6, 1967·Nature·U Mittwock
Mar 1, 1966·Proceedings of the National Academy of Sciences of the United States of America·J A Huberman, A D Riggs
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May 1, 1967·Annals of Human Genetics·M Mikkelsen
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May 15, 1965·Klinische Wochenschrift·R A PFEIFFERI SCHLUETER

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