PMID: 8615444Apr 1, 1996Paper

The pattern of pediatric solid malignant tumors in western Kenya, east Africa, 1979-1994: an analysis based on histopathologic study

The American Journal of Tropical Medicine and Hygiene
A M MakataH Itakura

Abstract

This study analyzed histopathologic specimens of 600 pediatric solid malignant tumors seen during the period 1979-1994 at the histopathology laboratories of the Rift Valley Provincial General Hospital in Nakuru, the Nyanza Provincial General Hospital in Kisumu, and the Uasin Gishu Hospital in Eldoret in western Kenya. The crude incidence rate of each malignancy per 100,000 children per year was calculated. The patterns of malignancies were examined with a focus on tumor incidence, age, sex, geographic, and ethnic distribution to relate the tumors to putative environmental and genetic causative factors. The six common tumors were Burkitt's lymphoma (33.5%), non-Hodgkin's lymphoma (21.8%), retinoblastoma (11.5%), Kaposi's sarcoma (6.1%), nephroblastoma (4.5%), and Hodgkin's disease (4.1%). Significantly high crude incidence rates for lymphomas and Kaposi's sarcoma showed a characteristic ethnogeographic distribution. The majority of the tumors were found concentrated around Lake Victoria and showed decreasing occurrence as one moved towards the semi-arid and highland areas. We concluded that environmental factors seem to play a major role in childhood tumors in western Kenya.

Citations

Aug 19, 2007·Tropical Medicine & International Health : TM & IH·Jeanette J RaineyRosemary Rochford
Jan 30, 2015·Journal of Cancer Epidemiology·Olakanmi Ralph AkindeOlatunji Michael Afolayan
Sep 26, 2015·BMC Research Notes·Sisay Yifru, Dagnachew Muluye
Apr 16, 2016·Pediatric Blood & Cancer·Chris A ReesUNKNOWN Baylor Pediatric HIV-Related Malignancy Consortium
Oct 5, 2006·International Journal of Cancer. Journal International Du Cancer·Jeanette J RaineyMark L Wilson
Jul 2, 2010·Pediatric Surgery International·Franklin C MargaronAlan Northcutt
Nov 23, 2011·World Journal of Pediatrics : WJP·Ayper KacarAta Turker Arikok
Jun 22, 2006·BMC Public Health·Edwin K Wiredu, Henry B Armah
Aug 14, 2012·World Journal of Pediatrics : WJP·Ochicha OchichaDalhatu Gwarzo
Mar 21, 2017·Current Opinion in Pediatrics·John K M Nyagetuba, Erik N Hansen
Jun 1, 2013·Archives of Pathology & Laboratory Medicine·Darcy A Kerr, Ronald Otto Christian Kaschula
Jan 19, 2005·Tropical Medicine & International Health : TM & IH·M M MeremikwuE O Alaje

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