The Pattern of Striatal Dopamine Depletion as a Prognostic Marker in De Novo Parkinson Disease

Clinical Nuclear Medicine
Seok Jong ChungP H Lee

Abstract

To investigate whether the patterns of striatal dopamine depletion could provide prognostic information on the clinical profiles of early-stage Parkinson disease (PD). Approximately 634 patients with drug-naive PD who underwent F-FP-CIT PET scans were followed up for at least 2 years. After quantifying dopamine transporter (DAT) availability in each striatal subregion, the patterns of striatal dopamine depletion of each patient were assessed based on (1) the degree of dopamine loss in the other striatal subregions compared to the posterior putamen (inter-subregional ratio [ISR]) and (2) the interhemispheric asymmetry of dopamine loss in the posterior putamen (asymmetry index [AI]). According to their patterns, we assessed the longitudinal changes in L-dopa-equivalent doses and L-dopa-induced dyskinesia (LID)-free times using the linear mixed model and Cox regression model, respectively. There was no significant correlation between the ISR and AI values (Pearson correlation coefficient, 0.150). The linear mixed model showed that higher AI values were associated with slower longitudinal increases in L-dopa-equivalent dose across time (P = 0.003), whereas ISR values were not (P = 0.154). The Cox regression model demonstrated that ...Continue Reading

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Citations

Jan 30, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·K BaikP H Lee
Aug 29, 2020·Journal of Movement Disorders·Seok Jong ChungYoung H Sohn
Mar 18, 2021·American Journal of Physical Medicine & Rehabilitation·Juliana M P ToldoAndré C Felício
Mar 24, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Seok Jong ChungPhil Hyu Lee
Apr 26, 2021·Brain : a Journal of Neurology·Seong Ho JeongPhil Hyu Lee
Jul 13, 2021·Journal of Parkinson's Disease·Marco CotogniDejan Georgiev
Jul 20, 2021·Journal of Parkinson's Disease·Han Soo YooPhil Hyu Lee

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