PMID: 34104824Jun 10, 2021Paper

The patterns and occupational distribution of hormonal abnormalities among men investigated for infertility in some centers in the southwest, Nigeria.

Journal of Clinical and Translational Research
Muyiwa Adeleye MoronkejiLawrence Tayo Ogundoju

Abstract

Male factor infertility results from dysfunction at various levels of spermatogenesis, sex hormone abnormalities, and occupation or workplace exposure to toxins are involved. This study was designed to determine the frequency of occupational distribution of men who were evaluated for infertility, the patterns of hormonal abnormalities, and to associate hormonal abnormalities with occupational categories in some centers in Osun State, Nigeria. Semen and 5 mL of whole blood were collected from the infertile men (n=319) who were referred to the laboratories for fertility investigation after physical and medical examination. Semen analysis was performed microscopically according to the World Health Organization manual while serum gonadotrophin-releasing hormone (GnRH), follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone, and prolactin were determined by Enzyme-linked Immunosorbent assay technique using reagents supplied by Biorex Diagnostics Limited, Antrim, United Kingdom. The subjects were grouped based on semen characteristics. More than half 164 (51.4%) of the subjects were within the age group of 31-40 years, followed by 70 (21.9%) in the age group of 21-30 years, while 67 (21.0%) was in the age group of...Continue Reading

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