PMID: 9178252Apr 1, 1997Paper

The Pbx family of proteins is strongly upregulated by a post-transcriptional mechanism during retinoic acid-induced differentiation of P19 embryonal carcinoma cells

Mechanisms of Development
P S Knoepfler, M P Kamps

Abstract

Retinoic acid (RA) induces expression of genes encoding the Hox family of transcription factors, whose differential expression orchestrates developmental programs specifying anterior-posterior structures during embryogenesis. Hox proteins bind DNA as monomers and heterodimers with Pbx proteins. Here we show that RA upregulates Pbx protein abundance coincident with transcriptional activation of Hox genes in P19 embryonal carcinoma cells undergoing neuronal differentiation. However, in contrast to Hox induction, Pbx upregulation is predominantly a result of post-transcriptional mechanisms. Interestingly, Pbx1, Pbx2, and Pbx3 exhibit different profiles of upregulation, suggesting possible functional divergence. The parallel upregulation of Pbx and Hox proteins in this model suggests an important role for transcriptional control by Pbx-Hox heterodimers during neurogenesis, and argues for precise control by RA.

References

Sep 1, 1992·Mechanisms of Development·A W Langston, L J Gudas
Dec 1, 1991·Molecular and Cellular Biology·K MonicaM L Cleary
Dec 17, 1987·Nature·V GiguereR M Evans
Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·A SimeoneE Boncinelli
Jan 1, 1988·Differentiation; Research in Biological Diversity·F MavilioP W Andrews
Jun 1, 1995·Mechanisms of Development·V J RobertsC Murre
Sep 26, 1995·Proceedings of the National Academy of Sciences of the United States of America·S T NeuteboomC Murre
Jul 1, 1995·Mechanisms of Development·M A van DijkC Murre
Jan 1, 1994·Cold Spring Harbor Symposia on Quantitative Biology·P J HurlinR N Eisenman
Aug 1, 1995·Molecular and Cellular Biology·M L PhelanM S Featherstone
Sep 2, 1994·Journal of Medicinal Chemistry·M F BoehmR A Heyman
Jan 1, 1993·Molecular and Cellular Biology·H Pöpperl, M S Featherstone
May 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·T N DearT H Rabbitts

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Citations

Jan 17, 2009·In Vitro Cellular & Developmental Biology. Animal·Anne S JürgensJürgen S Scheele
Dec 31, 2008·Journal of Cellular Biochemistry·Cristina C Fernandez, Lorraine J Gudas
Oct 7, 2004·Gene Expression Patterns : GEP·Steven C PruittRoy Heinaman
Jul 31, 2002·Differentiation; Research in Biological Diversity·Yi WeiGeoffrey Childs
Oct 1, 2013·Developmental Biology·Elise Corsetti, Natalia Azpiazu
Jan 1, 2008·Developmental Biology·Xiu YangStephen O'Gorman
Mar 21, 2000·American Journal of Human Genetics·L MoynihanC G Woods
Feb 20, 2020·Cancers·Richard Morgan, Hardev S Pandha
Jun 9, 2016·International Journal of Cancer. Journal International Du Cancer·Håkon RambergKristin Austlid Taskén
Dec 20, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Carla M CudaLaurence Morel
Jan 18, 2005·The Journal of Biological Chemistry·He HuangMark Featherstone
Jun 21, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Nilay ShahJeffrey Toretsky

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