The PDZ protein TIP-1 facilitates cell migration and pulmonary metastasis of human invasive breast cancer cells in athymic mice.

Biochemical and Biophysical Research Communications
M HanZ Han

Abstract

Tax-interacting protein 1 (TIP-1, also known as Tax1bp3) inhibited proliferation of colon cancer cells through antagonizing the transcriptional activity of beta-catenin. However, in this study, elevated TIP-1 expression levels were detected in human invasive breast cancers. Studies with two human invasive breast cancer cell lines indicated that RNAi-mediated TIP-1 knockdown suppressed the cell adhesion, proliferation, migration and invasion in vitro, and inhibited tumor growth in mammary fat pads and pulmonary metastasis in athymic mice. Biochemical studies showed that TIP-1 knockdown had moderate and differential effects on the beta-catenin-regulated gene expression, but remarkably down regulated the genes for cell adhesion and motility in breast cancer cells. The decreased expression of integrins and paxillin was accompanied with reduced cell adhesion and focal adhesion formation on fibronectin-coated surface. In conclusion, this study revealed a novel oncogenic function of TIP-1 suggesting that TIP-1 holds potential as a prognostic biomarker and a therapeutic target in the treatment of human invasive breast cancers.

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Citations

Oct 3, 2012·PloS One·Miaojun HanZhaozhong Han
Feb 12, 2013·Biochemical and Biophysical Research Communications·Sevil ZencirSmita Mohanty
Nov 14, 2012·Integrative Biology : Quantitative Biosciences From Nano to Macro·Daniel J FerraroDennis E Hallahan
Jun 3, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Calvin D LewisVaishali Kapoor

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