The peak phase of the proestrous prolactin surge is blocked by either posterior pituitary lobectomy or antisera to vasoactive intestinal peptide

Endocrinology
I MuraiN Ben-Jonathan

Abstract

The proestrous surge of PRL could result from a decrease in dopamine, an increase in PRL-releasing factor (PRF) or both. The objectives were to determine whether PRF from the posterior pituitary regulates the proestrous PRL surge, and to examine if there are interactions between PRF and vasoactive intestinal peptide (VIP). Posterior pituitary lobectomy (LOBEX) and passive immunization against VIP were employed. Adult cycling rats were subjected at 0900 h on proestrus to LOBEX or sham surgery (SHAM) under short term anesthesia, and were injected iv at 1330 h with 0.75 ml anti-VIP serum or normal rabbit serum. Jugular blood was collected hourly from 1400-2300 h and analyzed for PRL and LH by RIA. Oviductal ova were examined on estrus. The rise in plasma PRL in normal rabbit serum-treated SHAM rats was biphasic, with an early peak between 1500-1700 h and a lower plateau between 1900-2100 h. This rise was similar in profile and magnitude to that seen in intact rats. In contrast, LOBEX significantly attenuated the early peak, but did not alter the plateau. Passive immunization against VIP of either SHAM or LOBEX rats mimicked the effect of LOBEX alone on PRL release. Neither surgery nor anti-VIP serum affected the profile of the LH ...Continue Reading

Citations

Jan 1, 1989·Molecular Neurobiology·I Gozes, D E Brenneman
Jan 1, 1989·Progress in Neurobiology·N Ben-JonathanJ F Hyde
Mar 1, 1992·Molecular and Cellular Endocrinology·T E PorterL S Frawley
Jun 1, 1994·Journal of Neuroendocrinology·J DohanicsJ G Verbalis
Jun 12, 1992·Annals of the New York Academy of Sciences·D K SarkarN Mitsugi
Sep 1, 1992·Trends in Endocrinology and Metabolism : TEM·N Ben-Jonathan, J W Liu
Apr 1, 1994·Trends in Endocrinology and Metabolism : TEM·L Stephen Frawley
Jun 24, 2015·The Journal of Endocrinology·David R Grattan
Mar 24, 2017·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Yuya SatoIchiei Narita
Oct 4, 2000·Physiological Reviews·M E FreemanG Nagy
May 8, 2004·Chronobiology International·Stéphanie Perreau-LenzAndries Kalsbeek

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