PMID: 32535576Jun 15, 2020Paper

THE PECULIARITIES OF AVERAGE VALUES OF THE INDICES OF NON-VIRUS LABORATORY MARKERS OF ACTIVE EPSTEIN-BARR VIRUS INFECTION IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS

Georgian Medical News
U AbrahamovychO Romaniuk

Abstract

Epstein Barr Virus (EBV) originates from the subgroup of herpes viruses which have infected more than 90,0 % of adults worldwide. A special importance is attached to its affection of the patients with Systemic Lupus Erythematosus (SLE). We still have not found out which indices of active virus infection for SLE patients are the most productive and informative. We have involved 120 patients with the diagnosis of SLE. The results of the evaluation of changes in blood parameters indicate that in patients with active EBV infection the average hemoglobin content is significantly lower, and the average number of monocytes, the average content of AlT, C-RP, total protein and γ-globulins is significantly higher than in patients without active EBV infection. There are also significantly higher values of anti-dsDNA and ANA in patients in the experimental group and a lower average value of the total complement, which may indicate a negative effect of the active virus on the immune system in patients with SLE. The patients with SLE with active EBV infection have the features of the average values of non-viral laboratory markers which are reliably higher than for those infected without active virus replication and they are the indices of hy...Continue Reading

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