PMID: 30237360Sep 22, 2018Paper

The Pedigree of Immuno-Oncology - History and Current Status of Immunotherapy against Malignancy

Gan to kagaku ryoho. Cancer & chemotherapy
Yasuyuki Sugiyama

Abstract

Since 1970s immunotherapy had been thought to be one of feasible strategies against malignancy. During that time nonspecific immunotherapy by biological response modifiers(BRMs), peptide vaccine therapy, dendritic cell-based vaccine therapy, adoptive cell therapy, targeting therapy by use of monoclonal antibody, and so on, had been investigated but finally they resulted in disappointment because of inappropriate clinical trials followed by limited efficacy. Therefore the understanding of clinical oncologists in regard to immunotherapy had been considerably poor until 2010. Nevertheless the steady efforts had made a progress in immunotherapy against malignancy, especially in the field of immunological targeting therapy by use of monoclonal antibodies related to immune checkpoint pathway. Even though there are plenty of problems to be resolved especially in terms of biomarker, the blockade of the immune checkpoint pathway could be effective in many patients with a variety of advanced malignant tumors, and in some cases inducing durable remissions. There is no longer any doubt that the immune system does work in tumor eradication. Nowadays immunotherapy has come of age and the same as surgical resection, chemotherapy and radiother...Continue Reading

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.

Related Papers

Molecular Biology Reports
Ilgin Kimiz-GebologluCigir Biray-Avci
Nihon rinsho. Japanese journal of clinical medicine
Yutaka Kawakami
Advances in Experimental Medicine and Biology
Xiaoyu Li, Xia Bu
© 2022 Meta ULC. All rights reserved