The pedunclopontine nucleus and Parkinson's disease

Neurobiology of Disease
Cecilia TubertD James Surmeier

Abstract

In the last decade, scientific and clinical interest in the pedunculopontine nucleus (PPN) has grown dramatically. This growth is largely a consequence of experimental work demonstrating its connection to the control of gait and of clinical work implicating PPN pathology in levodopa-insensitive gait symptoms of Parkinson's disease (PD). In addition, the development of optogenetic and chemogenetic approaches has made experimental analysis of PPN circuitry and function more tractable. In this brief review, recent findings in the field linking PPN to the basal ganglia and PD are summarized; in addition, an attempt is made to identify key gaps in our understanding and challenges this field faces in moving forward.

Citations

Apr 18, 2020·The European Journal of Neuroscience·Cecilia Tubert, Mario Gustavo Murer
Sep 12, 2020·Cells·Enrico Zampese, D James Surmeier
Nov 13, 2020·Science Advances·Martin T HenrichD James Surmeier
Feb 2, 2021·Journal of Parkinson's Disease·Sommer L Amundsen-HuffmasterColum D MacKinnon
Jul 25, 2021·Cell·Manuel J Ferreira-PintoSilvia Arber

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