Abstract
The pedunculopontine nucleus (PPN), which is located in the upper brainstem, contains cholinergic and non-cholinergic neurons, and has afferent and efferent connections to the basal ganglia and spinal cord. The PPN is known to be affected in adult-onset basal ganglia diseases, and we speculated that the PPN might be similarly insulted in developmental basal ganglia disorders. We immunohistochemically examined the expression patterns of acetylcholine esterase and tyrosine hydroxylase, markers of acetylcholinergic and catecholaminergic neurons, respectively, in the PPN pars dissipata (PPNd) of controls and patients with bilirubin encephalopathy (BE) and perinatal hypoxic ischemic encephalopathy with localized basal ganglia lesion (HIEbg). Controls showed an age-dependent change in the percentages of acetylcholinergic and catecholaminergic neurons. Three out of six BE cases and three out of six HIEbg cases showed a reduction in the percentage of acetylcholinergic neurons in the PPNd. Additionally, three BE cases demonstrated an increase in the percentage of catecholaminergic neurons. It is likely that the relative proportions of acetylcholinergic and catecholaminergic neurons in the PPN can be altered in developmental basal gangli...Continue Reading
References
Jan 1, 1991·Brain & Development·M HayashiY Morimatsu
Jan 1, 1990·Brain & Development·M HayashiH Sasaki
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·E C HirschF Javoy-Agid
Dec 10, 1984·Brain Research·R D Skinner, E Garcia-Rill
Apr 29, 1982·Brain Research·R P BarberE Roberts
Jan 1, 1997·Critical Reviews in Neurobiology·P WinnW L Inglis
Dec 24, 1997·Sleep·D B Rye
Apr 13, 1999·Neuroscience·K F ManayeD C German
Dec 14, 1999·Pathology International·Y Oda
May 19, 2000·Yonsei Medical Journal·M S LeeC D Marsden
Jan 22, 2003·Acta Neuropathologica·Satomi Kasashima, Yoshio Oda
Sep 18, 2004·Trends in Neurosciences·Juan Mena-SegoviaPeter J Magill
Dec 1, 2005·Neurobiology of Aging·O GeorgeW Mayo
Dec 2, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Toru ShinoeToshiya Manabe
Oct 7, 2006·The Journal of Physiology·Nicola OrigliaLuciano Domenici
Citations
Oct 1, 2010·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Masaharu HayashiNaoyuki Tanuma
Feb 8, 2014·Brain & Development·Yumi OkoshiMasaharu Hayashi
Jul 26, 2011·Brain & Development·Masaharu HayashiRyo Fukatsu
Aug 31, 2012·ISRN Neurology·Masaharu HayashiTohru Kodama
Nov 19, 2008·Journal of Neurology·Kaoru TakakusakiMasafumi Yano
Jan 27, 2009·Journal of Child Neurology·Ewa JamrozRon A Wevers