PMID: 7088754Jan 1, 1982Paper

The penetration of metronidazole into synovial fluid

Postgraduate Medical Journal
M A SattarJ E Holt

Abstract

Six patients with non-infected synovial effusions, associated either with inflammatory or degenerative arthropathy and requiring diagnostic or therapeutic aspiration, were given a short course of 400 mg metronidazole (Flagyl) 8-hourly for 3 doses. Serum and synovial fluid (SF) were sampled frequently during this time, and assayed for metronidazole by a specific high pressure liquid-chromatographic method. It was found that concentrations of metronidazole in SF reached those in serum after a short time-lag, and thereafter approximated to the serum concentration. With this regimen, metronidazole concentrations were readily achieved in synovial fluid, above the minimum inhibitory concentrations for most susceptible anaerobes. These results indicate that the drug freely enters the synovial fluid and suggests that metronidazole would prove effective in the treatment of septic arthritis due to anaerobic bacteria.

References

May 1, 1978·The Journal of Antimicrobial Chemotherapy·R W Barling, J B Selkon
Sep 1, 1979·The Journal of Antimicrobial Chemotherapy·G W HoughtonR Templeton
Apr 1, 1977·Scottish Medical Journal·A T Willis
Dec 11, 1976·British Medical Journal·S J Eykyn, I Phillips
May 1, 1975·Antimicrobial Agents and Chemotherapy·F P TallyS M Finegold
Sep 1, 1975·Annals of Internal Medicine·S M FinegoldF P Tally
Jan 12, 1974·Lancet·R F WellsC J McNeill
May 4, 1974·Lancet·R WiseD E Pelta
Nov 16, 1972·The New England Journal of Medicine·J G BartlettS M Finegold
Nov 1, 1972·Medicine·J G Bartlett, S M Finegold
Jan 1, 1973·Antimicrobial Agents and Chemotherapy·T D Wilkins, T Thiel
May 23, 1974·The New England Journal of Medicine·S L Gorbach, J G Bartlett
Dec 1, 1969·Arthritis and Rheumatism·I ZimentS M Finegold
Dec 1, 1970·American Journal of Diseases of Children·R M Katz, W Liebman
Nov 26, 1970·The New England Journal of Medicine·J M Felner, V R Dowell
May 16, 1966·JAMA : the Journal of the American Medical Association·D L Rimoin, J E Wennberg
Jan 1, 1981·Chemotherapy·I AmonC Mohr
May 24, 1958·British Medical Journal·J H KELLGRENK L BARNES
Feb 6, 1964·The New England Journal of Medicine·G W DOUGLASL SOKOLOFF

Citations

Jul 8, 2015·Therapeutic Delivery·Adeola O Adebisi, Barbara R Conway
Dec 6, 2002·Oncogene·Kathryn A TworkowskiWilliam P Tansey
Nov 1, 1991·Cancer Causes & Control : CCC·K A Steinmetz, J D Potter
Jan 1, 1983·Annals of the New York Academy of Sciences·E D RuberyR J Thompson
Dec 22, 2020·Anaerobe·Hassam AliNicole L Bolick

Related Concepts

Arthritis, Viral
Bacterial Infections
Bacteroides fragilis
Bacteroides Infections
Bayer 5360
Synovial Fluid

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