PMID: 7518011Jul 1, 1994Paper

The pentafraction of hydroxyethyl starch inhibits ischemia-induced compartment syndrome

The Journal of Trauma
A G HakaimS I Cho

Abstract

Pentafraction (PF), a solution of biodegradable hydroxyethyl starch macromolecules with molecular weights of 10 to 100 x 10(4) daltons, has been shown to minimize tissue edema by sealing interendothelial clefts at the capillary level. The effect of PF on ischemia-reperfusion-induced compartment syndrome was studied. Ten rabbits underwent bilateral femoral artery occlusion following ligation of branches from the terminal aorta to the popliteal artery. After 7 hours of ischemia, reperfusion was established with heparinized polyethylene shunts. Experimental animals (n = 5) received PF and control animals (n = 5) received normal saline (NS) as an intravenous infusion (30 mL/kg) for 1 hour, beginning 10 minutes after shunt placement. During reperfusion, anterior compartment pressure was continuously monitored in the left lower extremity. To quantitate oxidative metabolism, triphenyltetrazolium chloride (TTC) reduction (micrograms of TTC per milligram of protein) of tibialis anterior muscle from the right lower extremity was measured at femoral artery occlusion, 7 hours of ischemia, and 2 hours of reperfusion. In the NS group, anterior compartment pressure significantly increased from the end of the ischemic interval, 10.8 +/- 4.14 t...Continue Reading

Citations

Nov 14, 1998·Injury·M Mars, G P Hadley
Mar 13, 2002·Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery·D RittooR K Vohra
Dec 24, 2005·Critical Care Medicine·Joachim Boldt
May 2, 2008·Critical Care Medicine·Linda A KirschenbaumMark E Astiz
Jun 14, 2003·European Journal of Anaesthesiology·G Marx
Mar 21, 2009·Seminars in Vascular Surgery·Friedhelm Beyersdorf, Christian Schlensak
Jun 1, 2006·Journal of the American College of Surgeons·David S KauvarThomas J Walters
Dec 3, 2011·The American Journal of Pathology·Tracy L CriswellShay Soker
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Jun 18, 2005·Acta Pharmacologica Sinica·Ji-Xian WangJing Zhang
Dec 4, 2012·Journal of Women & Aging·Doyel Dasgupta, Subha Ray

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