PMID: 7540293Jan 1, 1995Paper

The peptidergic innervation of the human superficial temporal artery: immunohistochemistry, ultrastructure, and vasomotility

Peptides
I J OlesenLars Edvinsson

Abstract

The peptidergic innervation of the human superficial temporal artery was investigated by means of immunohistochemical, ultrastructural, and in vitro pharmacological techniques. A dense network of nerve fibers was found in the adventitia. The majority of the nerve fibers displayed immunoreactivity for tyrosine hydroxylase and neuropeptide Y (NPY). A moderate supply of perivascular nerve fibers displayed either acetylcholinesterase activity or immunoreactivity for vasoactive intestinal peptide (VIP), peptide histidine methionine-27 (PHM), and calcitonin gene-related peptide (CGRP). Only a few nerve fibers displayed substance P (SP), neurokinin A (NKA), and neuropeptide K (NPK) immunoreactivity. In double immunostained preparations, SP immunoreactivity was co-localized with NPK and CGRP in the same nerve fibers. Ultrastructural studies revealed the presence of numerous axon variocosities at the adventitial--medial border. NPY, VIP, and CGRP immunoreactivities occurred in the same type of large granular vesicles, but in morphological distinct nerve profiles. NPY had, in general, no direct vasoconstrictor effect. However, at a low concentration of NPY contractile response induced by NA (10(-7)-10(-6)M) was 9-15 times enhanced. The N...Continue Reading

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Citations

Jun 29, 2005·Naunyn-Schmiedeberg's Archives of Pharmacology·Raphaela VerheggenAlberto J Kaumann
Jan 6, 2011·Journal of Neural Transmission·Elliot Shevel
Jun 8, 2001·Peptides·S GulbenkianL Edvinsson
Aug 5, 2006·Cephalalgia : an International Journal of Headache·J M HansenM Ashina
Aug 30, 2008·Cephalalgia : an International Journal of Headache·L Edvinsson, P Tfelt-Hansen
Jan 16, 2009·Cephalalgia : an International Journal of Headache·H W SchytzM Ashina
Jun 30, 2011·Indian Journal of Plastic Surgery : Official Publication of the Association of Plastic Surgeons of India·Sreenivasulu ReddyKeerthana Prasad
Oct 16, 2013·Journal of the Neurological Sciences·Maria A NagelDon Gilden
Jan 29, 2011·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Hakima MechichePhilippe Devillier
Oct 8, 2014·Journal of Neurology, Neurosurgery, and Psychiatry·Marina Del FiaccoCarlo Cianchetti
Jun 22, 2012·Cephalalgia : an International Journal of Headache·Carlo Cianchetti
Jan 1, 1995·Cephalalgia : an International Journal of Headache·L Edvinsson, P J Goadsby
Apr 25, 2018·Nature Reviews. Neurology·Lars EdvinssonDiana N Krause

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