The perception of rheumatoid arthritis core set measures by rheumatologists. Results of a survey

Rheumatology
D AletahaJosef S Smolen

Abstract

To investigate the perception of values of individual core set measures by rheumatologists, and how it differs across measures and across physicians. We designed a survey in which 44 international expert rheumatologists explicitly marked positions on the scales of seven core-set measures that in their opinion corresponded to cut-points between remission, low, moderate and high disease activity. The measures comprised swollen and tender joint counts (SJC, TJC), CRP, ESR, patient and evaluator global assessments of activity (PGA, EGA), and the Health Assessment Questionnaire Disability Index (HAQ). The interpretation of measures across physicians was most consistent for ESR and PGA, while for CRP and joint counts there was most variation. Joint counts and CRP implied active disease at lower relative values (using normalized scales) than did PGA, EGA or ESR (P < 0.01 for most comparisons; Bonferroni-adjusted Wilcoxon signed rank test), and most physicians tended to tolerate higher numbers of tender joints than swollen joints to define similar levels of disease activity. Given these cut-points, more RA patients in a typical cross-sectional cohort would be regarded as being in remission according to joint counts (SJC, 35%; TJC, 55%)...Continue Reading

References

Feb 14, 2004·Annals of the Rheumatic Diseases·J S Smolen, D Aletaha
Jun 25, 2005·Annals of the Rheumatic Diseases·D Aletaha, M M Ward
Sep 6, 2005·Arthritis and Rheumatism·Daniel AletahaJosef S Smolen

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Citations

Dec 10, 2009·Clinical Rheumatology·Simon J OtterKaren Walker-Bone
Apr 11, 2013·Clinical Rheumatology·Yasser El Miedany
Mar 11, 2010·Annals of the Rheumatic Diseases·Josef S SmolenUNKNOWN T2T Expert Committee
Feb 24, 2009·Arthritis Research & Therapy·Josef S Smolen, Daniel Aletaha
Jul 29, 2011·Reumatología clinica·Alejandro Balsa
Dec 8, 2009·Rheumatic Diseases Clinics of North America·Daniel Aletaha, Josef S Smolen
Aug 7, 2007·Best Practice & Research. Clinical Rheumatology·Daniel Aletaha, Josef S Smolen
Mar 20, 2016·Joint, Bone, Spine : Revue Du Rhumatisme·Thomas KramsArnaud Constantin
Oct 30, 2016·Arthritis Research & Therapy·Elena NikiphorouLaure Gossec
Feb 18, 2014·The Journal of Rheumatology·Margot J WalterJolanda J Luime
Aug 15, 2020·Rheumatology·Aprajita JagpalAngelo Gaffo
Oct 4, 2020·Clinical Rheumatology·Enrico De LorenzisElisa Gremese
Nov 21, 2015·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Fausto SalaffiMarwin Gutierrez
Jul 23, 2016·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Margot J M WalterJolanda J Luime

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