PMID: 9426365Jan 14, 1998Paper

The percutaneous absorption and skin distribution of lindane in man. I. In vivo studies

Human & Experimental Toxicology
I P DickF M Williams

Abstract

1. The absorption and distribution of lindane through skin was examined using human volunteers. Two different preparations were employed, one with acetone as the vehicle and the other, a commercial product, consisting primarily of white spirit as the solvent base. 2. The mean peak plasma concentrations of lindane following exposure to the acetone and white-spirit based applications were 0.91 and 0.47 ng/ml, respectively. The similarity between these levels did not reflect the 40-fold higher dose of lindane in the acetone vehicle. White spirit enhanced the penetration of lindane with respect to the acetone vehicle, highlighting the influence of vehicle upon percutaneous absorption. Low levels of trichlorophenol glucuronide metabolites, but no lindane, were detected in the urine. 3. The exposure site was washed at 6 h to mimic a decontamination procedure at the end of a working day. The proportion of the applied dose unabsorbed by 6 h was 80% and 10% for the acetone and the white spirit-based formulation, respectively. Small areas of the exposed site were tape stripped at 6 and 24 h to assess any lindane that may be associated with the stratum corneum. High levels were observed in the stratum corneum at 6 h exposure (up to 30% of...Continue Reading

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Jan 14, 1998·Human & Experimental Toxicology·I P DickF M Williams

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Citations

Dec 13, 2000·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·E Schnetz, M Fartasch
Jan 29, 2011·Journal of Toxicology and Environmental Health. Part a·John H RossJeffrey H Driver
Sep 29, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Barbara A WetmoreRussell S Thomas
Jan 30, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Barbara A WetmoreRussell S Thomas
Aug 20, 2010·Environmental Health : a Global Access Science Source·Leslie LondonClaudio Colosio
Dec 23, 2006·Environmental Health Perspectives·Caroline Cox, Michael Surgan
Jul 24, 2001·Drugs·T C RoosD R Bickers
Apr 18, 2008·Ecotoxicology and Environmental Safety·Emma Martínez-LópezAntonio J García-Fernández
Mar 10, 2015·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Gøril Eide FlatenNataša Škalko-Basnet
Feb 1, 2006·Environmental Toxicology and Pharmacology·Faith M Williams
Aug 8, 2008·Human & Experimental Toxicology·I Jakasa, S Kezic
Jan 14, 1998·Human & Experimental Toxicology·I P DickF M Williams
Feb 3, 2004·Skin Pharmacology and Physiology·U JacobiJ Lademann
Oct 1, 2009·Toxicology Mechanisms and Methods·Ivana KmeticJasna Kniewald
Nov 12, 2005·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Ute JacobiJürgen Lademann

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