The percutaneous assessment of regional and acute coronary hot unstable plaques by thermographic evaluation (PARACHUTE) study: a prospective reproducibility and prognostic clinical study using thermography to predict future ischemic cardiac events

International Journal of Cardiovascular Interventions
Stefan VerheyePatrick W Serruys

Abstract

Intravascular thermography is currently being considered as a valuable tool in assessing macrophage-rich plaques. Since it is unknown what the prognostic value is of non-obstructive atherosclerotic plaques showing temperature heterogeneity, we designed the PARACHUTE study, a prospective, reproducibility, and prognostic clinical study using thermography in patients presenting with an unstable coronary syndrome. The primary endpoint of the study is the predictive value of temperature heterogeneity towards the occurrence of ischemic coronary events and hospitalization for ischemia and/or angina. The secondary endpoints are the predictive value of high-risk plaques associated with the development of future cardiac events, assessment of safety of the procedure, assessment of temperature reproducibility and heterogeneity in coronary arteries, as defined by the total thermal burden towards the occurrence of any cardiac event. Based on an event rate of death and myocardial infarction at 1 year of 10%, a sample size of 260 patients with presumed coronary artery disease, and positive troponin level who are scheduled to undergo an intervention will be included. All three main epicardiac vessels will undergo angiography and thermography at...Continue Reading

References

Jul 1, 1988·Journal of the American College of Cardiology·J A AmbroseV Fuster
Aug 1, 1995·Circulation·E FalkV Fuster
Mar 1, 1994·Journal of the American College of Cardiology·J E MullerG H Tofler
Jan 14, 1999·The New England Journal of Medicine·R Ross
May 16, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·R VirmaniS M Schwartz
Aug 18, 2001·Circulation Research·Z A Fayad, V Fuster
Aug 25, 2001·Lancet·S R MehtaUNKNOWN Clopidogrel in Unstable angina to prevent Recurrent Events trial (CURE) Investigators
Sep 1, 2001·Lancet·UNKNOWN Assessment of the Safety and Efficacy of a New Thrombolytic Regimen (ASSENT)-3 Investigators
Jul 5, 2002·The New England Journal of Medicine·Antonino BuffonAttilio Maseri
Jun 13, 2003·Journal of Interventional Cardiology·Pedro R Moreno, James E Muller
Jun 13, 2003·Journal of Interventional Cardiology·Chris L de KorteAnton F van der Steen

❮ Previous
Next ❯

Citations

Apr 25, 2006·Journal of the American College of Cardiology·Mohammad MadjidS Ward Casscells
Jun 15, 2007·Journal of the American College of Cardiology·Paul Schoenhagen
Jun 23, 2007·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Ashraf HamdanRan Kornowski
Mar 18, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Joanna WykrzykowskaRoger Laham

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.